MK-801 powerfully protects against N-methyl aspartate neurotoxicity |
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| Affiliation: | 1. College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China;1. College of Materials Science and Engineering, Hunan University, Changsha 410082, PR China;2. Jiangsu Jinling Special Paint Co., Ltd., Yangzhou 225212, PR China;1. Department of Chemistry Lewis & Clark College Portland, OR 97219, United States;2. Department of Chemistry Portland State University Portland, OR 97207, United States;1. State Key Laboratory of Heavy Oil Processing, College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China;1. Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;2. Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
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| Abstract: | Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotoxin, that its antagonism is specific for N-methyl-aspartate toxicity, is non-competitive and does not entail inhibition of excitatory amino acid receptor binding. |
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