| 姜黄素-PLGA纳米粒的制备与药效学评价 |
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| 引用本文： | 朱志新,钱颖,曹青日,杨世林,崔京浩. 姜黄素-PLGA纳米粒的制备与药效学评价[J]. 中成药, 2011, 33(5): 776-779 |
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| 作者姓名： | 朱志新 钱颖 曹青日 杨世林 崔京浩 |
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| 作者单位： | 苏州大学医学部药学院,江苏,苏州,215123 |
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| 基金项目： | 科技部国际科技合作项目(2009DFA31330); 国家“重大新药创制”科技重大专项(2009ZX09502-009) |
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| 摘 要： | 目的 制备和考察姜黄素-聚乳酸/羟基乙酸纳米粒(Cur-PLGA NPs)对小鼠溃疡性结肠炎的影响.方法 乳化-溶剂挥发法制备Cur-PLGA NPs,透射电镜观察外观形态,动态激光粒度分析仪分析微粒大小及分布,测定载药量.通过自由饮用5%硫酸葡聚糖钠(DSS)溶液7 d,诱导小鼠溃疡性结肠炎,考察Cur-PLGA NPs对模型动物疾病活动指数(DAI)的影响.结果 姜黄素PLGA纳米粒的平均大小为(419±12)nm,载药量为(15.8±1.0)%.小鼠DAI(第7天)从小到大顺序依次为:正常组<纳米粒高剂量组<5-氨基水杨酸组<混悬液组<纳米粒中剂量组<纳米粒低剂量组<阴性对照组.结论 姜黄素PLGA纳米粒对溃疡性结肠炎小鼠具有较好防治作用.
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| 关 键 词： | 姜黄素 PLGA 纳米粒 溃疡性结肠炎 疾病活动指数 小鼠 |
Preparation and pharmacodynamic evaluation of curcumine-PLGA nanoparticles |
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| ZHU Zhi-xin , QIAN Ying , CAO Qing-ri , YANG Shi-lin , CUI Jing-hao. Preparation and pharmacodynamic evaluation of curcumine-PLGA nanoparticles[J]. Chinese Traditional Patent Medicine, 2011, 33(5): 776-779 |
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| Authors: | ZHU Zhi-xin QIAN Ying CAO Qing-ri YANG Shi-lin CUI Jing-hao |
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| Affiliation: | ZHU Zhi-xin,QIAN Ying,CAO Qing-ri,YANG Shi-lin,CUI Jing-hao*(School of Pharmacy,Medical College of Soochow University,Suzhou 215123,China) |
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| Abstract: | AIM To prepare and investigate curcumin loaded PLGA nanoparticles(Cur-PLGA NPs) on the ulcerative colitis(UC) in mouse.METHODS Cur-PLGA-NPs were prepared by modified emulsion-solvent evaporation method.The shape and size of Cur-PLGA-NPs were observed by TEM and dynamic laser scattering analyzer,respectively.Loading capacity of drug in nanoparticles was determined.UC model mice were induced by oral administration of 5% sodium dextran sulfate(DSS) for 7 days,the pharmacodynamic effect of Cur-PLGA NPs was inve... |
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| Keywords: | curcumine PLGA nanoparticles ulcerative colitis disease active index mouse |
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