| 乌药总生物碱的大鼠在体肠吸收研究 |
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| 引用本文： | 谭蓉,侴桂新,冯年平,赵继会,王志.乌药总生物碱的大鼠在体肠吸收研究[J].中成药,2011,33(5):787-790. |
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| 作者姓名： | 谭蓉 侴桂新 冯年平 赵继会 王志 |
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| 作者单位： | 1. 上海中医药大学,上海,201203
2. 上海中医药大学,上海,201203;上海中药标准化研究中心,上海,201203 |
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| 基金项目： | 国家科技部“重大新药创制”科技重大专项(2009ZX09103-374); 教育部新世纪优秀人才支持计划(NECT08-0898) |
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| 摘 要： | 目的 研究乌药总生物碱的大鼠在体肠吸收情况,为口服剂型设计提供理论依据.方法 采用大鼠在体单向肠灌流实验,以去甲异波尔定做为指标性成分,采用HPLC法测定吸收部位、灌肠液中乌药总生物碱质最浓度,考察灌肠液的pH值对乌药总生物碱吸收的影响.结果 乌药总乍物碱在各肠段吸收较好;不同质量浓度的吸收速率常数(ka)和表观吸收系数(Papp)无显著性差异(P>0.05);灌流液小同pH值的ka和Papp值有显著性差异(P<0.05).结论 乌药总生物碱在全肠段吸收较好,不受其质量浓度的影响.提示其吸收机制主要为被动扩散吸收.
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| 关 键 词： | 在体肠吸收 乌药总乍物碱 单向灌流法 高效液相色谱法 |
In situ intestinal absorption of total alkaloids from Linderae Radix in rats |
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| TAN Rong
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CHOU Gui-xin
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FENG Nian-ping
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ZHAO Ji-hui
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WANG Zhi.In situ intestinal absorption of total alkaloids from Linderae Radix in rats[J].Chinese Traditional Patent Medicine,2011,33(5):787-790. |
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| Authors: | TAN Rong CHOU Gui-xin FENG Nian-ping ZHAO Ji-hui WANG Zhi |
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| Institution: | TAN Rong1,CHOU Gui-xin1,2,FENG Nian-ping1*,ZHAO Ji-hui1,WANG Zhi1(1.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,2.Shanghai R.& D.Centre for Standardization of Chinese Medicines,China) |
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| Abstract: | AIM To study the in situ intestinal absorption of total spicebush alkaloids(TSA) from Linderae Radix in rats.METHODS TSA concentration in rat intestinal segment was determined by HPLC with norisoboldine as the marker.Unidirectional enteroclysm was employed to investigate the interaction between intestinal segments,TSA content concentration and pH of TSA on absorption rate constant(ka) of TSA and the intestinal apparent permeation coefficients(Papp).RESULTS TSA was well absorbed at all segments of intestine ... |
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| Keywords: | in situ intestinal absorption total spicebush alkaloids Linderae Radix Unidirectional enteroclysm HPLC rat |
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