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| 玉屏风颗粒治疗过敏性鼻炎的实验研究 | |
| 引用本文： | 文洁,朱建梅,李婕,袁广明,向飞军.玉屏风颗粒治疗过敏性鼻炎的实验研究[J].中成药,2011,33(6):934-937. |
| 作者姓名： | 文洁 朱建梅 李婕 袁广明 向飞军 |
| 作者单位： | 1. 中山大学药物开发中心,广东广州,510080 2. 中山大学中山医学院,广东广州,510080 3. 广东环球制药有限公司,广东顺德,528000 |
| 摘 要： | 目的 观察玉屏风颗粒(黄芪、白术和防风)治疗过敏性鼻炎的药效作用.方法 建立卵蛋白致大鼠及豚鼠过敏性鼻炎模型,并观察玉屏风颗粒对过敏性鼻炎症状的改善作用；通过大鼠被动皮肤过敏实验测定IgE效价,并观察药物对大鼠鼻黏膜病理学变化的影响.结果 1.对过敏性鼻炎大鼠连续用药7 d,大鼠IgE抗体水平降低,抗血清样本呈阴性；连续用药14 d,可以明显改善大鼠过敏鼻炎症状,与模型组比较P＜0.01.2.对豚鼠过敏性鼻炎模型连续给药10 d后,玉屏风颗粒组症状好转率＞80％；玉屏风颗粒治疗组鼻黏膜的嗜酸细胞增多,鼻黏膜溃疡、腺体增生以及充血水肿等病理学改变得到明显改善(P＜0.05).结论 玉屏风颗粒对过敏性鼻炎大鼠和豚鼠具有良好的抗过敏作用. |
| 关 键 词： | 过敏性鼻炎 被动皮肤过敏(PCA) IgE 玉屏风颗粒 |
Experimental study of Yupingfeng Granule on allergic rhinitis in rat and guinea pig |
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| WEN Jie , ZHU Jian-mei , LI Jie , YUAN Guang-ming , XIANG Fei-jun.Experimental study of Yupingfeng Granule on allergic rhinitis in rat and guinea pig[J].Chinese Traditional Patent Medicine,2011,33(6):934-937. | |
| Authors: | WEN Jie ZHU Jian-mei LI Jie YUAN Guang-ming XIANG Fei-jun |
| Institution: | WEN Jie1,ZHU Jian-mei1,LI Jie1,YUAN Guang-ming2,XIANG Fei-jun3(1.Drug Research and Development Center of Sun Yat-sen University,Guangzhou 510080,China,2.Zhongshan Medical College of Sun Yat-sen University,3.Guangdong Global Pharmaceutical Co.,Ltd.,Shunde 528000,China) |
| Abstract: | AIM To study effects of Yupingfeng Granule(Atragali Radix,Astractylodis macrocephalae Rhizoma,and Saposhnikoviae Radix) on allergic rhinitis in rat and guinea pig.METHODS Establishing guinea pig and rat allergic rhinitis models by repeating sensitization with ovalbumin,the improvement was observed of allergic rhinitis symptoms and the nasal pathologic changes after being treated with Yupingfeng Granule;the titer of specific IgE was measured in the rat homologous passive cutaneous anaphylaxis model.RESULTS 1... |
| Keywords: | allergic rhinitis passive cutaneous anaphylaxis IgE Yupingfeng Granule rat guinea pig |
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