白子菜提取物对SHR大鼠靶器官损伤的保护作用研究

目的 评价白子菜水提物对高血压诱导的组织器官损伤的保护作用.方法 根据基础血压将40只SHR大鼠分成5组:空白对照组(蒸馏水)、阳性对照组(卡托普利,25 mg/kg)、白子菜水提物高、中、低剂量组(2 g生药/kg、1g生药/kg、0.5 g生药/kg),每天灌胃给药,持续7周,每周称重并记录心率1次,第7周末,通过肉眼和显微观察各鼠心、脑、肾和脾脏的外观或病理变化并予以分级评分.结果 经过7周实验,与空白组比较,白子菜高、中剂量组均能明显抑制心肌细胞肥大和肾小球(管)萎缩或代偿性肥大(P＜0.01).高剂量组能显著改善脾脏中央动脉硬化变性现象(P＜0.05),降低左室壁厚/右室壁厚,增加肾皮质厚/肾髓质厚(P＜0.05).而低剂量仅对肾脏病理改变有显著保护作用(P＜0.05).结论 白子菜提取物对高血压引起的主要器官损伤具有明显的保护作用.

Protective effect of Gynura divaricata extract on hypertension-induced target organs damage in spontaneous hypertensive rats

AIM To evaluate the protective effect of water extract of Gynura divaricata on hypertension-induced target organs damage in spontaneous hypertensive rats.METHODS According to baseline blood pressure,forty SHR rats were randomly divided into five groups: control group(distilled water),captopril group(125 mg/kg),three water extract of Gynura divaricata groups(low,middle and high dose).Each rat was administered i.g respectively for 7 weeks.Body weight and heart rate were measured by tail-cuff technique on each...