| 天麻提取物对血管性痴呆大鼠学习记忆及海马氧化损伤的作用 |
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| 引用本文： | 段小花,李秀芳,周宁娜,代蓉,吴盛友,林青. 天麻提取物对血管性痴呆大鼠学习记忆及海马氧化损伤的作用[J]. 中成药, 2011, 33(7): 1138-1141 |
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| 作者姓名： | 段小花 李秀芳 周宁娜 代蓉 吴盛友 林青 |
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| 作者单位： | 云南中医学院药理教研室,云南昆明,650500 |
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| 基金项目： | 国家自然科学基金资助项目(30760305); 云南省应用基础研究计划面上项目(2007C076M) |
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| 摘 要： | 目的 观察天麻提取物对血管性痴呆(vascular dementia,VD)大鼠模型学习记忆能力及海马氧化损伤的影响.方法 采用双侧颈总动脉永久性结扎法,造成慢性脑灌注不足所致SD大鼠VD模型.术后分别灌胃给予天麻提取物高剂量7.29g/(kg·d)、低剂量0.81g/(kg·d)、尼莫地平30 mg/(kg·d),假手术组与模型组给予等体积的生理盐水,给药3周后,用Morris水迷宫检测各组大鼠逃避潜伏期和搜索距离；同时检测海马组织内丙二醛(MDA)量、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性.结果 与模型组相比,天麻提取物高剂量能明显缩短逃避潜伏期和搜索距离(P＜0.05),使大鼠海马组织内MDA量降低、SOD和GSH-PX活性及SOD/MDA比值升高(P＜0.05).结论 天麻提取物具有改善血管性痴呆模型大鼠的学习记忆能力,其机制可能与清除自由基、减轻海马区的氧化损伤有关.
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| 关 键 词： | 天麻提取物 血管性痴呆 学习记忆能力 氧化损伤 |
Effects of extract from Gastrodia elata Blume on learning-memory ability and oxidative damage to hippocampus with vascular dementia in rats |
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| DUAN Xiao-hua , LI Xiu-fang , ZHOU Ning-na , DAI Rong , WU Sheng-you , LIN Qing. Effects of extract from Gastrodia elata Blume on learning-memory ability and oxidative damage to hippocampus with vascular dementia in rats[J]. Chinese Traditional Patent Medicine, 2011, 33(7): 1138-1141 |
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| Authors: | DUAN Xiao-hua LI Xiu-fang ZHOU Ning-na DAI Rong WU Sheng-you LIN Qing |
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| Affiliation: | DUAN Xiao-hua,LI Xiu-fang,ZHOU Ning-na,DAI Rong,WU Sheng-you,LIN Qing(Yunnan College of Traditional Chinese Medicine,Kunming 650500,China) |
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| Abstract: | AIM To evaluate the effects of extract from Gastrodia elata Blume on learning-memory ability and the oxidative damage to hippocampus in rats with vascular dementia.METHODS The experimental vascular dementia model was established by chronic cerebral ischemia induced by permanent occlusion of bilateral carotid arteries.Sprague-Dawley rats were randomly divided into sham-operation group,model group,positive control(nimodipine) group and intervention group(fourteen rats each group).The intervention group were a... |
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| Keywords: | extract from Gastrodia elata Blume vascular dementia learning and memory oxidative damage |
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