| 母细胞性浆细胞样树突状细胞肿瘤病理学观察 |
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| 引用本文： | 刘恩彬,陈辉树,张培红,李占琦,孙琦,杨晴英,方立环,孙福军.母细胞性浆细胞样树突状细胞肿瘤病理学观察[J].诊断病理学杂志,2011,18(4). |
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| 作者姓名： | 刘恩彬 陈辉树 张培红 李占琦 孙琦 杨晴英 方立环 孙福军 |
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| 作者单位： | 中国医学科学院北京协和医学院血液病医院病理科,天津,300020 |
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| 摘 要： | 目的探讨母细胞性浆细胞样树突状细胞肿瘤(BPDCN)的组织病理学特点、诊断与鉴别诊断。方法对2例BPDCN患者的组织标本(1例为淋巴结、骨髓活检,另1例为皮肤、淋巴结、骨髓活检)进行HE染色及常规EliVision免疫组化观察与分析。结果 2例均为男性,年龄73岁和7岁。就诊时1例无症状、多发性皮肤病损,表面呈淡红色至紫红色的斑疹、丘疹、斑块、皮下结节;另1例无皮肤病损,以浅表淋巴结肿大就诊。组织学检查示1例侵犯淋巴结和骨髓;另1例侵犯皮肤、淋巴结和骨髓。镜下瘤细胞形态类似于淋巴母细胞或原始单核细胞。免疫组化示瘤细胞CD4、CD56、CD43和CD123(+),CD117、MPO、CD68、PAX5、CD20和CD3(-)。结论 BPDCN是一种罕见类型高度侵袭性血液肿瘤,除侵犯皮肤外还侵犯骨髓和淋巴结。CD4、CD56、CD43和CD123(+),不表达系别特异性标记,应注意与急性白血病、淋巴瘤区别。
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| 关 键 词： | 母细胞性浆细胞样树突状细胞肿瘤 病理学 免疫表型 骨髓活检 |
Pathologic observation of blastic plasmacytoid dendritic cell neoplasm |
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| LIU En-bin,CHEN Hui-shu,ZHANG Pei-hong,LI Zhan-qi,SUN Qi,YANG Qing-ying,FANG Li-huan,SUN Fu-jun.Pathologic observation of blastic plasmacytoid dendritic cell neoplasm[J].Chinese Journal of Diagnostic Pathology,2011,18(4). |
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| Authors: | LIU En-bin CHEN Hui-shu ZHANG Pei-hong LI Zhan-qi SUN Qi YANG Qing-ying FANG Li-huan SUN Fu-jun |
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| Institution: | LIU En-bin,CHEN Hui-shu,ZHANG Pei-hong,LI Zhan-qi,SUN Qi,YANG Qing-ying,FANG Li-huan,SUN Fu-jun(Department of Pathology,Hospital of Blood Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300020,China) |
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| Abstract: | Objective To explore the histopathology,diagnosis and differential diagnosis of blastic plasmacytoid dendritic cell neoplasms(BPDCN).Methods Tissue samples were obtained from 2 patients who were diagnosed as BPDCN,including skin and lymph node biopsies from 1 case and skin,lymph node and bone marrow biopsies from another.Histologic examination was performed on 4% buffered formalin fixed and hematoxylin-eosin(H-E)-stained sections with paraffin emdedded samples.Immunohistochemical study was conducted with ro... |
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| Keywords: | Blastic plasmacytoid dendritic cell neoplasm Pathology Immunophenotype Bone marrow biopsy |
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