| 当归四逆汤中阿魏酸在大鼠血清中含量测定及药动学研究 |
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| 引用本文： | 高宇勤,赵国平,江仁望.当归四逆汤中阿魏酸在大鼠血清中含量测定及药动学研究[J].中成药,2011,33(3):419-422. |
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| 作者姓名： | 高宇勤 赵国平 江仁望 |
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| 作者单位： | 1. 暨南大学医学院
2. 暨南大学药学院,广东,广州,510632 |
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| 基金项目： | 国家自然科学基金(30672679) |
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| 摘 要： | 目的:测定当归四逆汤(当归、白芍、桂枝、细辛、甘草、通草和大枣)口服后大鼠血清中阿魏酸血药浓度及药代动力学参数.方法:SD大鼠按20 g/kg灌胃给予当归四逆汤水煎液后,在7个时间点取血清,利用HPLC方法,通过外标法测定阿魏酸血药浓度,运用3P97软件计算药代动力学参数.结果:大鼠口服当归四逆汤水煎剂后阿魏酸药代动力学参数为Cmax 7.988 771 mg/L,AUC 7 861.507 80 mg/(L·min),Ke(1/min)0.001 222 669,Ka(1/min)0.019 541 92,t1/2(Ka)35.469 746 min,Tpeak 151.290 314 min.结论:大鼠口服当归四逆汤后阿魏酸吸收快,代谢比较慢.
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| 关 键 词： | 阿魏酸 药代动力学 高效液相色谱 当归四逆汤 |
Determination of ferulic acid serum concentration in Danggui Sini Decoction by HPLC and its pharmacokinetics in rats |
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| GAO Yu-qin
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ZHAO Guo-ping
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JIANG Ren-wang.Determination of ferulic acid serum concentration in Danggui Sini Decoction by HPLC and its pharmacokinetics in rats[J].Chinese Traditional Patent Medicine,2011,33(3):419-422. |
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| Authors: | GAO Yu-qin ZHAO Guo-ping JIANG Ren-wang |
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| Institution: | GAO Yu-qin1,ZHAO Guo-ping1,JIANG Ren-wang2(1.Medical College,Jinan University,2.School of Pharmacy,Guangzhou 510632,China) |
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| Abstract: | AIM:To measure concentrations and pharmacokinetics of ferulic acid in rats after oral adiministration of Danggui Sini Decoction(Angellicae sinensis radix,Paeoniae radix alba,Cinnamomi ramulus,Asari herba,Glycyrrhizae radix et rhizome,Medulla tetrapanacis,Jujubae fructus).METHODS:Serum concentration of ferulic acid was carried out by HPLC and its parameter of pharmacokinetics in SD rats after oral administration of Dang gui Sini Decoction(an oral dosage of 20 g/kg) via 3P97 software.RESULTS:Parameters of pha... |
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| Keywords: | ferulic acid HPLC pharmacokinetics Danggui Sini Decoction |
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