| 中心复合设计法优化香青兰口腔崩解片处方 |
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| 引用本文： | 马祖文,邢建国,王新春,李悦,薛桂篷,杨秀,任文东. 中心复合设计法优化香青兰口腔崩解片处方[J]. 中成药, 2011, 0(4): 603-607 |
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| 作者姓名： | 马祖文 邢建国 王新春 李悦 薛桂篷 杨秀 任文东 |
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| 作者单位： | 石河子大学药学院;新疆维吾尔自治区药物研究所;石河子大学医学院一附院; |
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| 基金项目： | 国家科技重大专项课题新药创制(2009ZX09103-448) |
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| 摘 要： | 目的选用中心复合设计法优化香青兰口腔崩解片处方。方法以PVPP(X1)、MCC(X2)和乳糖(X3)的用量为因变量,以崩解时间(Y)为自变量,分别用两因素相互作用模型(2FI)和三次多项式模型描述因变量和自变量之间的数学关系,绘制等高线图,确定较优处方并进行验证试验。结果优化后的处方为PVPP:38.5 mg,MCC:151.0 mg,乳糖:24.5mg。优化处方制备香青兰口腔崩解片平均崩解时间为30.46 s,预测值和测定值偏差的绝对值均<5%,3次多项式模型比两因素相互作用模型置信度高。结论中心复合设计法优化香青兰口腔崩解片的处方具有良好的预测性。
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| 关 键 词： | 香青兰 口腔崩解片 中心复合设计法 |
Optimization of the formulation of Greenorchid orally disintegrating tablet by central composite design |
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| MA Zu-wen,XING Jian-guo,WANG Xin-chun,,LI Yue,XUE Gui-peng,YANG Xiu,REN Wen-dong. Optimization of the formulation of Greenorchid orally disintegrating tablet by central composite design[J]. Chinese Traditional Patent Medicine, 2011, 0(4): 603-607 |
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| Authors: | MA Zu-wen XING Jian-guo WANG Xin-chun LI Yue XUE Gui-peng YANG Xiu REN Wen-dong |
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| Affiliation: | MA Zu-wen1,XING Jian-guo2,WANG Xin-chun1,3,LI Yue1,XUE Gui-peng2,YANG Xiu1,REN Wen-dong1(1.School of Pharmacy,Shihezi University,Shihezi 832000,China,2.Xinjiang Institute of Meteria,Urumqi 830004,3.The First Affiliated Hospital of Medical College,Xinjiang 832008,China) |
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| Abstract: | AIM To optimize the formulation of Greenorchid(Dracocephalum Moldavuca) orally disintegrating tablet by the central composite design(CCD).METHODS The amount of polyvinylpyrrolidone(PVPP),microcrystalline cellulose(MCC) and lactose were taken as the independent variables;disintegration time of tablet was taken as the dependent variable.two-factor-design and Cubic polynomial models were used to estimate the relationship between the dependent and independent variables,and contour plots was drawn to select the ... |
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| Keywords: | Dracocephalum Moldavuca orally disintegrating tablet central composite design |
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