二维化学位移成像检测帕金森病基底神经节代谢物浓度的应用

目的利用二维化学位移成像（2D CSI）检测帕金森病（PD）的基底神经节代谢物浓度。探讨PD的基底神经节代谢物浓度是否变化。评估2D CSI技术检测PD的价值。资料与方法符合临床诊断标准的PD患者26例。从健康志愿者中抽取与PD组年龄、性别相匹配的26名健康者作为正常对照组。采用2D CSI技术检测所有人组对象的双侧豆状核、尾状核的代谢物浓度，包括氮-乙酰天门冬氨酸／肌酸复合物（NAA／Cr），氮-乙酰天门冬氨酸／N碱复合物（NAA／Cho）以及Cho／Cr比值。比较PD组和正常对照组的基底神经节相对应核团的代谢物浓度之间的差异。结果PD组双侧豆状核的NAA／Cho和右尾状核的NAA／Cr、左侧尾状核的Cho／Cr比值明显低于正常对照组（P＜0．05）。左侧豆状核Cho／Cr比值明显高于正常对照组（P＜0．05）。结论PD患者的基底神经节代谢物浓度与正常人有差异。2D CSI作为一种可用于检测基底神经节代谢物浓度的无创伤性的方法，将成为检测正常脑的生理性和病变脑的病理性代谢物浓度的变化，尤其是神经元变性性疾病的一种重要手段。

Study of 2D Chemical Shift Imaging in the Basal Ganglia of Parkinson's Disease

Objective To discuss the levels of N acetylaspartate(NAA),choline(Cho),and cretine(Cr)in the basal ganglia of PD patients using 2D chemical shift imaging(2D CSI).Materials and Methods 26 patients with Parkinson's disease and 26 volunteers as control were examined by 2D CSI.2D CSI imaging acquisition was performed in bilateral caudate,lentiform.Voxels were selected in basal ganglia area,and 1H-MRS were processed to determined the metabolite ratios,including NAA/Cho,NAA/Cr,Cho/Cr.Statistical analyses were performed using SPSS 11.5 software.Results Significant reduction of ratios of NAA/Cho,NAA/Cr and Cho/Cr and significant increase of ratio of Cho/Cr were observed respectively in the bilateral lentiform,right caudate,left caudate and left lentiform of PD patients compared with controls(P<0.05).Conclusion 1H-MRS can detect the abnormal metabolite changes of Parkinson's disease,which may play an important role in clinical studies and applications for various conditions of metabolic disorders of the human brain.