206株念珠菌属的临床分布及药物敏感性分析

目的：研究念珠菌属的临床分布及其对8种抗真菌药物的敏感性。方法：采用法国科玛嘉念珠菌属显色培养基分离鉴定菌株，用先德YO-8 Yeast One药敏板进行药敏试验。结果：206株念珠菌属中，以白色念珠菌最常见占63.50％，其次为热带念珠菌占12．40％、光滑念珠菌（10．20％）、克柔念珠菌（2.10％）、近平滑念珠菌属占1，90％，其他念珠菌占（3．90％）。念珠菌属感染的主要部位为肺、泌尿道、消化道：药物敏感试验显示：念珠菌属对两性霉素B、5-氟胞嘧啶、卡泊芬净敏感性最高，对咪唑类药物存在不同程度的耐药。结论：念珠菌属在临床标本中分离率较高，不同菌种对不同药物敏感性存在较大差异，临床上应重视念珠菌属的培养和药敏试验，合理选用抗真菌药物。

Analysis of Drug Susceptibility Tests and Clinical Distribution of 206 Strains in Candida spp.

Objective:To study clinical distribution and susceptibility tests of Candida spp.to eight antifungal agents.Methods:The CHRO Magar candida color medium was applied to isolate and identify Candida strains.The susceptibility tests were performed by the standard YO-8 Yeast panels. Results:Candida albicans were the most frequent organisms which accounted for 63.50% in all of 206 strains of Candida spp.Meanwhile,C.tropicalis,C.glabrata,C.Krusei,and C.parapsilosis accounted for 12.40%,10.20%,2.10%,1.90% and 3.90%,respectively.And the others accounted for only 3.90%. The infections caused by Candida spp.were mainly involved in lungs,urinary tract and digestive tract. The susceptibility tests indicated that amphotericin B,5-flucytosine and caspofungin were more effective than the other antifungal agents in Candida spp.However,the resistance to triazole antifugal agents could be shown.Conclusions:The detected rate of Candida spp is higher in clinical samples. Drug sensitivity of different Candida to various antibiotics is different.Culturing and drug sensitivity of Candida should be put on important place and antibiotics should be reasonably used based on suscep- tibility tests so as to reduce the drug resistance.