Endemic pemphigus vulgaris |
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Authors: | Rocha-Alvarez Rosicler Ortega-Loayza Alex G Friedman Horacio Campbell Iphis Aoki Valeria Rivitti Evandro A Dasher David Li Ning Diaz Luis A;Cooperative Group on Fogo Selvagem Research |
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Institution: | Department of Dermatology, Universidade Federal de Brasilia, Brasilia, Distrito Federal. |
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Abstract: | BACKGROUND: Investigators from Brasilia, Brazil, observed several patients with a mucocutaneous disease that resembles pemphigus vulgaris clinically and histologically but with epidemiological features of fogo selvagem. Our objective was to characterize antidesmoglein 3 and antidesmoglein 1 autoantibody profiles in these unique patients who reside in Goiania and Brasilia, Brazil, known endemic regions of fogo selvagem. OBSERVATIONS: We performed serological evaluation of 8 patients with a mucocutaneous disease clinically and histologically consistent with pemphigus vulgaris, as well as 27 healthy relatives of patients with fogo selvagem who reside in these endemic areas. Serum samples from all 8 patients bound desmoglein 3 by cold immunoprecipitation and from 6 patients by enzyme-linked immunosorbent assay, while serum samples from 4 patients bound desmoglein 1 by cold immunoprecipitation and by enzyme-linked immunosorbent assay. Antidesmoglein 3 autoantibodies were detected in 4 of 27 healthy donors by cold immunoprecipitation and by enzyme-linked immunosorbent assay, whereas antidesmoglein 1 autoantibodies were detected in 6 individuals by cold immunoprecipitation and in 3 individuals by enzyme-linked immunosorbent assay. CONCLUSION: These findings provide serological evidence of a new endemic variant of pemphigus vulgaris. |
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