| 化疗前食管癌组织中ERCC1 mRNA检测对化疗疗效的预测价值 |
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| 引用本文： | 樊青霞,邢国臣,吴欣爱,王瑞林,王留兴,李醒亚,李景云,宗红. 化疗前食管癌组织中ERCC1 mRNA检测对化疗疗效的预测价值[J]. 郑州大学学报(医学版), 2005, 40(1): 64-67 |
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| 作者姓名： | 樊青霞 邢国臣 吴欣爱 王瑞林 王留兴 李醒亚 李景云 宗红 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科,郑州,450052;郑州市中心医院肿瘤康复风湿科,郑州,450000 |
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| 摘 要： | 目的探讨化疗前食管癌组织中ERCC1 mRNA水平对CDDP/5-FU化疗疗效的预测价值.方法采用半定量RT-PCR检测20例初治食管癌患者化疗前癌组织中ERCC1 mRNA水平.患者接受2周期CDDP/5-FU化疗后,分析化疗疗效与化疗前ERCC1 mRNA水平的关系.结果化疗前癌组织中ERCC1 mRNA水平中位值0.956.11例化疗有效的ERCC1 mRNA水平均值为0.799,9例化疗无效者为1.147,差异具有统计学意义(P＜0.05),化疗前食管癌组织中ERCC1 mRNA水平与化疗疗效呈负相关(rs=-0.515,P=0.02).ERCC1 mRNA高、低水平组患者的年龄、性别、病理类型、分化程度、TNM分期及化疗疗效间差异均无统计学意义(P＞0 05).结论化疗前食管癌组织中ERCC1 mRNA水平对CDDP/5-Fu化疗疗效的预测价值,值得扩大样本进一步研究.
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| 关 键 词： | 食管肿瘤 ERCC1 联合化疗 治疗效果 |
| 修稿时间： | 2004-02-20 |
Predictive value of detecting ERCC1 mRNA in esophageal cancer tissue on chemotherapy efficacy |
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| FAN Qingxia ),XING Guochen ),WU Xinai ),WANG Ruilin ),WANG Liuxing ),LI Xingya ),LI Jingyun ),ZONG Hong ) ). Predictive value of detecting ERCC1 mRNA in esophageal cancer tissue on chemotherapy efficacy[J]. Journal of Zhengzhou University: Med Sci, 2005, 40(1): 64-67 |
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| Authors: | FAN Qingxia ) XING Guochen ) WU Xinai ) WANG Ruilin ) WANG Liuxing ) LI Xingya ) LI Jingyun ) ZONG Hong ) ) |
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| Affiliation: | FAN Qingxia 1),XING Guochen 2),WU Xinai 1),WANG Ruilin 1),WANG Liuxing 1),LI Xingya 1),LI Jingyun 2),ZONG Hong 2) 1)Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Oncology,Zhengzhou Central Hospital,Zhengzhou 450000 |
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| Abstract: | Aim: To evaluate the predictive value of detecting ERCC1 mRNA in esophageal cancer tissue on chemotherapy efficacy .Methods: Twenty patients with esophageal cancer who had not received any treatment before accepted two cycles chemothereapy of cisplatin and fluorouracil combination. ERCC1 mRNA level in esophageal tumor tissue was detected by semi-quantitative RT-PCR before chemotherapy.The relationship between chemotherapy efficacy and ERCC1 mRNA level in esophageal cancer tissue before chemotherapy was analyzed.Results: The median ERCC1 mRNA level was 0.956(ranging from 0.37 to 1.61). The mean ERCC1 mRNA level of 11 responding patients was 0.799, whereas that of non-responding patients was 1.147(P<0.05).The ERCC1 mRNA level was negatively correlated with chemotherapy efficacy( r s=-0.515, P=0.02).Conclusion: The predictive value of detecting ERCC1 mRNA level in esophageal cancer on chemotherapy efficacy before chemotherapy is valuable to further study. |
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| Keywords: | esophageal neoplasm ERCC1 combination chemotherapy efficacy |
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