维持性血透患者六种肝炎病毒感染的调查研究

目的：了解维持性血液透析患者六种肝炎病毒感染情况，探讨其与输血、透析时间、肝功能的关系。方法：对１６７例维持性血液透析患者进行调查，采用第二代酶联免疫法（ＥＬＩＳＡ）检测ＨＡＶ、ＨＢＶ、ＨＥＶ、ＨＧ，用套式ＰＣＲ法检测经输血传播的肝炎病毒（ＴＴＶ）ＤＮＡ，并按血透时间、输血次数等分组进行对比分析。结果：ＨＡＶ、ＨＢＶ、ＨＣＶ、ＨＨＥＶ、ＨＧＶ、ＴＴＶ感染率分别为０％、２０．４％、５５．７％、０％、

INVESTIGATION OF SIX TYPES OF HE PATIT IS VIRUS INFECTION IN DIALYSIS PATIENTS

OBJECTIVE To evaluate the incidences of six types of hepatitis virus infection in dialysis patients, and to discuss its related risk factors as transfusion,length of dialysis period and hepatic dysfunction. METHODOLOGY 167 cases of chronic dialysis patients were included. Serum markers of HAV, HBV, HCV,HEV and HGV infection were detected by second generation ELISA, and transfusion transmissible virus(TTV) DNA was detected by Nest PCR. All patients were divided into groups according to the period of dialysis and frequency of transfusion. RESULTS The prevalences of HAV,HBV,HCV,HEV,HGV and TTV were 0%,20 4%,55 7%,0%,10 7% and 26 1% respectively. Transfusion and the years of dialysis were found to be the related risk factor to hepatitis virus infection. ALT and Glo in the patients with positive HBV and HCV serum indicatives were significantly higher than those of the control group. CONCLUSION The prevalence of TTV infection is high in dialysis patients, and the abnormalities of hepatic function are easily seen in the HBV and HCV infection groups.