| 小蘖硷对离体豚鼠心房的作用 |
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| 引用本文： | 王玉,赵娇玲,方达超,江明性.小蘖硷对离体豚鼠心房的作用[J].中国药理学通报,1986(3). |
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| 作者姓名： | 王玉 赵娇玲 方达超 江明性 |
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| 作者单位： | 同济医科大学药理教研室
(王玉，赵娇玲，方达超)，同济医科大学药理教研室(江明性) |
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| 摘 要： | 在豚鼠离体左心房,小蘖硷(Berberine,Ber)10~(-4)M能明显增强收缩力32±8％,延长FRP38％,降低肾上腺素(Adr)诱发自律性之闽浓度,但不明显影响兴奋性。在豚鼠离体右心房上,Bcr除增加收缩力22±7％外,还明显减慢自搏频率15％,并能桔抗Adr的正性频率作用,但对其正性肌力作用则无影响。以上结果可能与Ber的抗心律失常作用有关。
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| 关 键 词： | 小蘖硷 离体心房 肌力作用 频率作用 自律性 兴奋性 |
EFFECTS OF. BERBERINE ON THE ISOLATED ATRIA OF GUINEA PIGS |
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| WANG Yu ZHAO Jiao-ling FANG Da-chao JIANG Ming-xing.EFFECTS OF. BERBERINE ON THE ISOLATED ATRIA OF GUINEA PIGS[J].Chinese Pharmacological Bulletin,1986(3). |
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| Authors: | WANG Yu ZHAO Jiao-ling FANG Da-chao JIANG Ming-xing |
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| Institution: | WANG Yu ZHAO Jiao-ling FANG Da-chao JIANG Ming-xing |
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| Abstract: | In the isolated left atria of guinea pigs, Berberine ( Ber) 10-4 M was found to enhance the contractility by 32±8%, prolong the functional refractory period ( FRP ) by about 38% and increase the auto-maticity induced by adrenaline ( Adr ) but no influence upon its excitability was observed.
In the spontaneously beating atria, Ber, in addition to its positive inotropic effect (+22±7%),showed negative chronotropic action (15%) .The chronotropic action of Adr was antagonized by Ber but not its positive inotropic effect. These results suggest that the pharmacological effects may be relevant to its antiarrythmic action. |
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| Keywords: | Berberine Inotropic activity Chronotropic activity Isolated atria Automaticity Excitability |
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