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Dendritic cell-mediated T cell polarization |
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| Authors: | de Jong Esther C Smits Hermelijn H Kapsenberg Martien L |
| Affiliation: | (1) Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands;(2) Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands;(3) Present address: Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands |
| Abstract: | Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4+ T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response. |
| Keywords: | Th1 cells Th2 cells Regulatory T cells Cytokines Costimulatory molecules |
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