| 麻黄常规粉体与超微粉体中麻黄碱在小鼠肺部药物浓度的比较研究 |
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| 引用本文： | 罗正红,邹龙,桂卉,颜红,郭锦明,李志华,蔡光先.麻黄常规粉体与超微粉体中麻黄碱在小鼠肺部药物浓度的比较研究[J].中南药学,2011,9(6):464-466. |
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| 作者姓名： | 罗正红 邹龙 桂卉 颜红 郭锦明 李志华 蔡光先 |
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| 作者单位： | 1. 湖南中医药大学,长沙,410208
2. 湖南中医药大学，长沙410208；冷水江市中医院，湖南冷水江417500 |
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| 基金项目： | 国家科技公关课题，湖南省科技厅科研科技计划重点项目 |
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| 摘 要： | 目的测定麻黄常规粉体与超微粉体中麻黄碱在小鼠肺部的浓度,探讨不同粒径麻黄粉体对麻黄碱在小鼠肺部浓度的影响。方法小鼠以相同剂量灌胃给予常规与超微2种麻黄粉体后,在规定的时间点摘取肺,匀浆处理后用HPLC法测定其中麻黄碱的含量。结果超微粉体组肺内麻黄碱含量明显高于常规粉体组。结论超微粉体可提高麻黄药物在小鼠肺内的药物浓度。
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| 关 键 词： | 麻黄 麻黄碱 常规粉体 超微粉体 肺 分布 |
Concentration of ephedrine in traditional and ultra-micro ephedra powder in the lung of mice |
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| LUO Zheng-hong,ZOU Long,GUI Hui,YAN Hong,GUO Jin-ming,LI Zhi-hua,CAI Guang-xian.Concentration of ephedrine in traditional and ultra-micro ephedra powder in the lung of mice[J].Central South Pharmacy,2011,9(6):464-466. |
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| Authors: | LUO Zheng-hong ZOU Long GUI Hui YAN Hong GUO Jin-ming LI Zhi-hua CAI Guang-xian |
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| Institution: | LUO Zheng-hong1,ZOU Long1,GUI Hui1,YAN Hong1,GUO Jin-ming1,LI Zhi-hua1,2,CAI Guang-xian1(1.Hunan University of Traditional Chinese Medicine,Changsha 410208,2.Traditional Chinese Medicine Hospital of Lengshuijiang,Lengshuijiang Hunan 417500) |
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| Abstract: | Objective To study the concentration of ephedrine in ephedra traditional powder and ultra-micro powder in the lung of mice,and discuss the effect of different particle sizes of ephedra on distribution.Methods The mice were divided into 2 groups:one was given traditional powder and the other was given ultra-micro powder.The distribution of ephedrine in the lung was analysed by HPLC method.Results The ultra-micro powder distributed faster than the traditional powder,and the concentration was obviously higher ... |
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| Keywords: | herba ephedrae ephedrine traditional powder ultra-micro powder lungs distribution |
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