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| TRH-03肠溶微丸的制备及其处方优化 | |
| 引用本文： | 贾娜,冒华,胡凯莉,奉建芳.TRH-03肠溶微丸的制备及其处方优化[J].中南药学,2011,9(10):736-739. |
| 作者姓名： | 贾娜 冒华 胡凯莉 奉建芳 |
| 作者单位： | 1. 上海中医药大学穆拉德中药现代化研究中心,上海201203;广西中医学院药学院,南宁510004 2. 苏州天人合生物技术有限公司,江苏苏州,215021 3. 上海中医药大学穆拉德中药现代化研究中心,上海,201203 |
| 摘 要： | 目的研究TRH-03肠溶微丸的处方优化及制备工艺。方法采用流化床包衣法,以载药量及释放量为考察指标,对TRH-03肠溶微丸的处方、上药和包衣工艺进行了优化。结果制得的3批肠溶微丸圆整度好,其载药率分别为35.63%、35.04%、35.64%;在人工胃液中保持不释药,人工肠液中45min内释放率分别为89.58%、88.96%、88.36%,载药量稳定且重现性好,体外释放度符合中国药典2010年版二部的要求。结论本方法制备工艺简单易行,重复性好,适合进一步的工业化生产。 |
| 关 键 词： | TRH-03 肠溶微丸 流化包衣 |
Preparation and formulation optimization of enteric-coated TRH-03 pellets |
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| JIA Na,MAO Hua,HU Kai-li,FENG Jian-fang.Preparation and formulation optimization of enteric-coated TRH-03 pellets[J].Central South Pharmacy,2011,9(10):736-739. | |
| Authors: | JIA Na MAO Hua HU Kai-li FENG Jian-fang |
| Institution: | JIA Na1,2,MAO Hua3,HU Kai-li1,FENG Jian-fang1(1.Murad Research Center for Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,2.School of Pharmaceutical Sciences,Guangxi College of Traditional Chinese Medicine,Nanning 530001,3.Suzhou Tianrenhe Biotech Ltd,Suzhou Jiangsu 215021) |
| Abstract: | Objective To study the preparation and formulation optimization of the enteric coated TRH-03 pellets.Methods The enteric-coated TRH-03 pellets were prepared with fluid bed coating technology.The drug loading rate and dissolution of the pellets were used as indexes to optimize the coating formulation.Results The prepared TRH-03 pellets had excellent geometric roundness and a drug loading rate of 35.63%,35.04%,and 35.64%.The TRH-03 pellets were stable in artificial gastric juice while in artificial intestinal... |
| Keywords: | TRH-03 enteric coated pellet airflow coating method |
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