| 布地奈德纳米混悬剂的制备及药效学评价 |
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| 引用本文： | 张源,张建华,张剑萍. 布地奈德纳米混悬剂的制备及药效学评价[J]. 中南药学, 2011, 9(9): 661-664. DOI: 10.3969/j.issn.1672-2981.2011.09.007 |
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| 作者姓名： | 张源 张建华 张剑萍 |
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| 作者单位： | 1. 上海市第六人民医院小儿呼吸内科,上海,200233
2. 上海市第六人民医院药剂科,上海,200233 |
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| 摘 要： | 目的研究一种新型的布地奈德(BUD)纳米混悬吸入剂,评价其在豚鼠哮喘模型上的治疗作用,以期开发糖皮质激素新剂型用于哮喘长期吸入治疗。方法以HPMC、SLS为基质材料,采用高压乳匀技术制备BUD纳米混悬剂,并进行体外特征评价,体内过敏实验及药效学研究。结果 BUD纳米混悬剂为稳定、均匀的混悬液,纳米粒径呈正态分布,均值为122.5 nm;制备的纳米混悬剂对豚鼠无过敏反应,能明显控制哮喘发作,并呈剂量依赖性;纳米混悬治疗组中白细胞总数和肺泡灌洗液中细胞总数及嗜酸性粒细胞明显低于模型组(P<0.05),且嗜酸性粒细胞减少呈剂量依赖性。结论 BUD纳米混悬液能够提高药物在体内吸收程度,显著抑制气道内炎性细胞浸润,是一种适合哮喘患者吸入的新剂型。
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| 关 键 词： | 布地奈德 纳米混悬剂 药效学 哮喘 |
Preparation and in vivo evaluation of budesonide nanosuspension |
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| ZHANG Yuan,ZHANG Jian-hua,ZHANG Jian-ping. Preparation and in vivo evaluation of budesonide nanosuspension[J]. Central South Pharmacy, 2011, 9(9): 661-664. DOI: 10.3969/j.issn.1672-2981.2011.09.007 |
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| Authors: | ZHANG Yuan ZHANG Jian-hua ZHANG Jian-ping |
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| Affiliation: | ZHANG Yuan1,ZHANG Jian-hua1,ZHANG Jian-ping2(1.Department of Pediatric Respiratory,Shanghai Sixth People's Hospital,Shanghai 200233,2.Department of Pharmacy,Shanghai 200233) |
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| Abstract: | Objective To develop a novel nanosuspension delivery of budesonide(BUD) and study its efficacy on guinea pigs with asthma.Methods BUD nanosuspension with hydrorpropyl methyl cellulose(HPMC) and sodium lauryl sulfate(SLS) was prepared respectively,and characterized in terms of diameter,and allergy experiment,pharmacodynamics.Results The features of BUD nanosuspension were described as smooth surface and 122.5 nm in average diameter with normal distribution.There was no allergy in vivo.It effectively controll... |
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| Keywords: | budesonide nanosuspension pharmacodynamics asthma |
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