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| 不同透皮吸收促进剂对士的宁透过离体猪皮的影响 | |
| 引用本文： | 许李,杨梓懿,汤淮波,吴萍,李翠飞,尹晓玲. 不同透皮吸收促进剂对士的宁透过离体猪皮的影响[J]. 中南药学, 2011, 9(10): 763-766. DOI: 10.3969/j.issn.1672-2981.2011.10.014 |
| 作者姓名： | 许李 杨梓懿 汤淮波 吴萍 李翠飞 尹晓玲 |
| 作者单位： | 1. 湘潭大学化学学院药学教研室,湖南湘潭411105;湖南中医药大学药学院炮制教研室,长沙410000 2. 湖南中医药大学药学院炮制教研室,长沙,410000 3. 湘潭大学化学学院药学教研室,湖南湘潭,411105 |
| 基金项目： | 湖南省科技厅项目(编号:2010FJ3107); 湖南省中医药管理局项目(编号:2009103) |
| 摘 要： | 目的初步探索开发士的宁透皮给药系统的可能性。方法采用体外透皮扩散法在规定时间点取样,高效液相色谱法测样品中士的宁的含量;以时间为横坐标,士的宁累积透皮量为纵坐标作图求透皮吸收速率、滞后时间等参数。结果各促透剂对士的宁促渗作用由弱至强依次为吐温-80<桉叶素<薄荷醇<香芹酮<油酸<柠檬烯<萜品油烯。结论选用适当的透皮吸收促进剂,士的宁体外透皮吸收速率可达到开发透皮给药系统的需要。 |
| 关 键 词： | 士的宁 透皮吸收促进剂 透皮扩散 |
Effect of chemical enhancers on the permeation of strychnine across pig skin in vitro |
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| XU Li,YANG Zi-yi,TANG Huai-bo,WU Ping,LI Cui-fei,YIN Xiao-ling. Effect of chemical enhancers on the permeation of strychnine across pig skin in vitro[J]. Central South Pharmacy, 2011, 9(10): 763-766. DOI: 10.3969/j.issn.1672-2981.2011.10.014 | |
| Authors: | XU Li YANG Zi-yi TANG Huai-bo WU Ping LI Cui-fei YIN Xiao-ling |
| Affiliation: | XU Li1,2,YANG Zi-yi2,TANG Huai-bo1,WU Ping1,LI Cui-fei1,YIN Xiao-ling1(1.Department of Pharmacy,Chemistry College of Xiangtan University,Xiangtan Hunan 411105,2.College of Pharmacy,Traditional Chinese Medicine of Hunan University,Changsha 410000) |
| Abstract: | Objective To evaluate the possibility of transdermal delivery system of strychnine.Methods Receptor solution was sampled at designed interval and determined by HPLC.The cumulative amount of strychnine permeating per unit area versus time was plotted to obtain transdermal parameter such as flux and lag time.Results Oleic acid,tween 80,carvone,cineole,menthol,terpinolene,and limonene had a strong enhancing effect on the permeation of strychnine,and terpinolene and limonene exhibited the most potent enhancing ... |
| Keywords: | strychnine penetration enhancer transdermal diffusion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |