| 卡维地洛对那格列奈在大鼠体内药物动力学的影响 |
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| 引用本文： | 刘茜,邵馨,赵辉,褚雨,刘艳芳.卡维地洛对那格列奈在大鼠体内药物动力学的影响[J].中南药学,2011,9(6):427-430. |
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| 作者姓名： | 刘茜 邵馨 赵辉 褚雨 刘艳芳 |
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| 作者单位： | 沈阳药科大学药物分析实验室,沈阳,110016 |
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| 摘 要： | 目的研究卡维地洛对那格列奈在大鼠体内药物动力学的影响。方法 10只健康雄性Wistar大鼠随机分成2组(单独给药组和联合给药组),用HPLC-MS/MS法测定血浆中那格列奈的浓度。结果单独用药与联合用药组Cmax分别为(1 868±226.3)和(992.8±246.0)μg.L-1,AUC0-t分别为(1 532.1±526.5)和(822.5±298.0)μg.h.L-1,AUC0-∞分别为(1 546.2±530.7)和(845.1±312.0)μg.h.L-1,均具有显著性差异(P<0.05),其他药动学参数无显著性差异(P>0.05)。结论联合用药后卡维地洛抑制了那格列奈的吸收。
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| 关 键 词： | 卡维地洛 那格列奈 高效液相色谱-质谱联用 药物动力学 |
Effect of carvedilol on pharmacokinetics of nateglinide in rats |
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| LIU Qian,SHAO Xin,ZHAO Hui,CHU Yu,LIU Yan-fang.Effect of carvedilol on pharmacokinetics of nateglinide in rats[J].Central South Pharmacy,2011,9(6):427-430. |
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| Authors: | LIU Qian SHAO Xin ZHAO Hui CHU Yu LIU Yan-fang |
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| Institution: | LIU Qian,SHAO Xin,ZHAO Hui,CHU Yu,LIU Yan-fang(Shenyang Pharmaceutical University,Shenyang 110016) |
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| Abstract: | Objective To investigate the effect of carvedilol on pharmacokinetics of nateglinide in rats.Methods Ten healthy male Wistar rats were divided into 2 groups（ig administration of nateglinide alone and combination of carvedilol and nateglinide）.The plasma concentration of nateglinide was determined by HPLC-MS/MS.Results The pharmacokinetic parameters of nateglinide in the healthy rats after ig administration of nateglinide alone and combination of carvedilol and nateglinide were as follows： Cmax was（103.0±26.6） and（72.6±9.23） g·L-1,AUC0-t was（1 532.1±526.5） and（822.5±298.0）μg·h·L-1;AUC0-∞ was（1 546.2±530.7） and（845.1±312.0） μg·h·L-1,which showed significance difference（P〈0.05）.There were no significant differences in the other pharmacokinetic parameters between the two groups（P〉0.05）.Conclusion The absorption of nateglinide is lower after combination with carvedilol. |
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| Keywords: | carvedilol nateglinide HPLC-MS/MS pharmacokinetics |
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