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| 博落回提取物对大鼠急性酒精性肝损伤的保护作用 | |
| 引用本文： | 肖俐,易键,赵静,徐丽,刘柏炎,刘德明,曾建国. 博落回提取物对大鼠急性酒精性肝损伤的保护作用[J]. 中南药学, 2011, 9(7): 485-489. DOI: 10.3969/j.issn.1672-2981.2011.07.002 |
| 作者姓名： | 肖俐 易键 赵静 徐丽 刘柏炎 刘德明 曾建国 |
| 作者单位： | 1. 湖南中医药大学,长沙410208;湖南省中药提取工程研究中心,长沙410331 2. 湖南中医药大学,长沙,410208 3. 湖南农业大学,长沙,410083 4. 湖南中医药大学,长沙410208;湖南农业大学,长沙410083;湖南省中药提取工程研究中心,长沙410331 |
| 基金项目： | 科技部国际科技合作计划项目 |
| 摘 要： | 目的探讨博落回提取物(Macleaya Cordataextract,MCE)对大鼠急性酒精性肝损伤的保护作用及其作用机制。方法采用白酒灌胃法建立大鼠急性酒精性肝损伤模型。将60只SD大鼠随机分为模型组,正常组,阳性药物组,MCE高、中、低剂量组,每组10只。检测各组大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)和肝匀浆超氧化物岐化酶(SOD)活性及丙二醛(MDA)含量,观察肝脏病理形态学改变,并测定肝组织中肿瘤坏死因子(TNF-α)、白介素(IL-1β)的表达水平。结果与模型组相比较,经MCE预防性治疗后,大鼠血清中ALT、AST、LDH活性显著降低(P<0.01),肝组织中SOD活力明显增强、MDA含量显著下降、TNF-α与IL-1β表达水平显著降低(P<0.01),形态学观察显示MCE能明显改善肝组织病理形态。结论 MCE能改善肝功能,对大鼠急性酒精性肝损伤具有保护作用,其机制可能与其减轻肝脏炎症、抗脂质过氧化作用有关。 |
| 关 键 词： | 博落回提取物 酒精性肝损伤 保护作用 |
Protective effect of Macleaya Cordata extract on alcohol-induced acute hepatic injury in rats |
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| XIAO Li,YI Jian,ZHAO Jing,XU Li,LIU Bo yan,LIU De-ming,ZENG Jian-guo. Protective effect of Macleaya Cordata extract on alcohol-induced acute hepatic injury in rats[J]. Central South Pharmacy, 2011, 9(7): 485-489. DOI: 10.3969/j.issn.1672-2981.2011.07.002 | |
| Authors: | XIAO Li YI Jian ZHAO Jing XU Li LIU Bo yan LIU De-ming ZENG Jian-guo |
| Affiliation: | XIAO Li1,3,YI Jian1,ZHAO Jing2,XU Li1,LIU Bo-yan1,LIU De-ming2,ZENG Jian-guo1,2,3*(1.Hunan University of Traditional Chinese Medicine,Changsha 410208,2.Hunan Agricultural University,Changsha 410128,3.Herb Extract Engineering Research Center,Changsha 410331) |
| Abstract: | Objective To investigate the protective effect and mechanism of Macleaya Cordata extract(MCE) on alcohol-induced acute hepatic injury in rats.Methods Acute hepatic injury model was made by alcohol administration by gavage.Sixty SD rats were randomly divided into 6 groups:a normal control group,a model group,a positive control group,a high-dose MCE group,a middle-dose MCE group,and a low-dose MCE group.The serum ALT,AST,and LDH levels were measured.MDA and SOD in the liver homogenates were analyzed.Histopath... |
| Keywords: | Macleaya Cordata extract alcohol-induced hepatic injury protective effect |
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