| 环氧化酶2 mRNA在前列腺癌组织中的表达 |
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| 引用本文： | 杨明山,夏术阶,刘海涛,孙晓文,韩邦旻,吴吉涛,鲁军,凌桂明,唐孝达.环氧化酶2 mRNA在前列腺癌组织中的表达[J].中华男科学杂志,2006,12(2):159-161. |
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| 作者姓名： | 杨明山 夏术阶 刘海涛 孙晓文 韩邦旻 吴吉涛 鲁军 凌桂明 唐孝达 |
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| 作者单位： | 上海交通大学附属第一人民医院泌尿外科,上海,200080 |
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| 摘 要： | 目的:探讨环氧化酶2(COX-2)mRNA在前列腺癌(PCa)组织中的表达及其意义。方法:采用RT-PCR方法检测32例PCa组织中COX-2 mRNA的表达并测定COX-2/GAPDH的比值,7例正常前列腺组织作为对照。结果:7例正常前列腺组织无COX-2 mRNA表达。COX-2/GAPDH与PCa G leason评分、分期呈正相关(P均<0.05)。结论:COX-2在PCa的发生发展中起重要的正性调节因子的作用。COX-2与PCa的恶性程度和进展有关,可作为判断PCa预后的指标。
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| 关 键 词： | 前列腺癌 环氧化酶2 |
| 文章编号： | 1009-3591（2006）02-0159-03 |
| 收稿时间： | 2005-04-22 |
| 修稿时间： | 2005-07-25 |
Expression and Implication of Cyclooxygenase-2 mRNA in Prostate Cancer |
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| YANG Ming-shan,XIA Shu-jie,LIU Hai-tao,SUN Xiao-wen,HAN Bang-min,WU Ji-tao,LU Jun,LING Gui-ming,TANG Xiao-da.Expression and Implication of Cyclooxygenase-2 mRNA in Prostate Cancer[J].National Journal of Andrology,2006,12(2):159-161. |
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| Authors: | YANG Ming-shan XIA Shu-jie LIU Hai-tao SUN Xiao-wen HAN Bang-min WU Ji-tao LU Jun LING Gui-ming TANG Xiao-da |
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| Institution: | Department of Urology, the First Hospital of Shanghai Jiaotong University, Shanghai 200080, China. yangmingshandachuan@126.com |
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| Abstract: | Objective: To investigate the relationship between cyclooxygenase-2(COX-2) mRNA expression and the biological behaviors of prostate carcinoma(PCa).Methods: The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined.Seven normal prostate tissues were served as control. Results: The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative.There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa.There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.Conclusion: COX-2 mRNA play an important role in occurrence and progression of the PCa.COX-2 is a tumor marker which may be the possible prognostic factor of PCa. Natl J Androl,2006,12(2):159-161 |
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| Keywords: | prostate carcinoma cyclooxygenase-2 |
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