| 直接凝血酶抑制剂在急性冠脉综合征中的应用 |
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| 引用本文： | 孙涛,张红菊,吴永全. 直接凝血酶抑制剂在急性冠脉综合征中的应用[J]. 心血管病学进展, 2005, 26(3): 254-257 |
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| 作者姓名： | 孙涛 张红菊 吴永全 |
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| 作者单位： | 首都医科大学附属北京友谊医院心血管中心,北京,100050 |
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| 摘 要： | 冠心病的病理生理机制是破裂粥样斑块基础上血栓的形成。斑块中的组织因子可触发凝血,导致凝血酶的形成,并进一步触发凝血过程。因此,凝血酶抑制剂在预防冠脉内血栓形成的过程中起十分重要的作用。
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| 关 键 词： | 凝血酶抑制剂 急性冠脉综合征 |
| 文章编号： | 1004-3934(2005)03-0254-04 |
| 修稿时间： | 2004-05-26 |
Direct Thrombin Inhibitors in Acute Coronary Syndromes |
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| SUN Tao,Zhang Hong-Ju,Wu Yong-Quan. Direct Thrombin Inhibitors in Acute Coronary Syndromes[J]. Advances in Cardiovascular Diseases, 2005, 26(3): 254-257 |
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| Authors: | SUN Tao Zhang Hong-Ju Wu Yong-Quan |
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| Abstract: | Most acute coronary syndromes are caused by intracoronary thrombus superimposed on disrupted atherosclerotic plaque.Tissue factor in the lipid-rich core of the plaque initiates coagulation.A potent platelet agonist,thrombin recruits additional platelets to the site of vascular injury.Thrombin also converts fibrinogen to fibrin,which serves to stabilize platelet-rich thrombi formed at sites of plaque disruption.Therefore,thrombin inhibitor plays an important role in intracoronary thrombus formation. |
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| Keywords: | Direct thrombin inhibitor Acute coronary syndromes |
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