埃索美拉唑、莫沙必利与铝碳酸镁联合应用治疗胃食管反流性咳嗽

目的观察埃索美拉唑、莫沙必利和铝碳酸镁联合应用治疗胃食管反流性咳嗽的临床疗效。方法 35例胃食管反流性咳嗽患者随机为A组(n=12),B组(n=12)和C组(n=11),分别采用埃索美拉唑(20毫克/次,2次/日)+铝碳酸镁(1000毫克/次,3次/日)+莫沙比利(5毫克/次,3次/日)、埃索美拉唑+莫沙比利及铝碳酸镁+莫沙比利治疗。8周后评价临床咳嗽症状变化,8周后评价内镜下有效率。结果治疗8周后,A、B和C组临床症状总有效率分别为91.6%、91.6%和72.7%,内镜下黏膜炎症恢复总有效率分别为100%、91.6%和90.9%,A组临床症状显效率与B和C组有显著性差异(P<0.05),总有效率与C组存在显著性差异;内镜下黏膜改变有效率与C组相比存在显著性差异(P<0.05)。结论埃索美拉唑、莫沙必利和铝碳酸镁联合规律治疗可以改善胃食管反流引起的慢性咳嗽症状。

Efficacy of Esomeprazole Combined with Mosapride and Hydrotaleite in Treatment of Gastroesophageal Reflux Cough

Objective To evaluate the effect of esomeprazole combined with mosapride and hydrotalcite on gastroesophageal reflux cough. Methods A total of 35 gastroesophageal reflux cough patients were randomly divided into groups A （n= 12）, B （n= 12） and C （n= 11）, treated with esomeprazole（20 mg, bid） plus hydrotalcite（1000 mg, tid） plus mosapride（5 mg, tid）, esomepra zole plus mosapride, and hydrotacite plus mo sapride, respectively. The clinical symptoms of cough were observed and analyzed after 8 weeks of treatment. Endoscopy was performed to evalu~ate the effective rate in the three groups. Results After 8 weeks of treatment, the total improvement rates were 91.6 %, 91.6 % and 72.7 % in group A, B and C, and the change of gastric mucosa effective rates detected by endoscopy were 100 %, 91.6 % and 90.9 %, respectively. The clinical symptoms improvement rate （P〈0.05） were markedly higher in group A than those in B and C group, and the effective rate had significant difference compared with group C. The change of gastric mucosa effective rate （P〈0.05） detected by endoscopy had significant difference compared with group C. Conclusion Esomeprazole combined with mosapride and hydrotalcite may be highly effective in the treatment of gastroesophageal reflux cough.