长效维生素A注射液的药效学研究

本实验目的在于定量观察,当饲料中缺乏维生素 A 时,长效维生素 A 注射液对小鼠肝脏和血清维生素 A 含量的影响。结果表明,喂以缺乏维生素 A 的饲料,可在20天内造成小鼠体内维生素 A 的缺乏;1次性腹腔或肌肉注射长效维生素 A,可通过缓慢的吸收作用,预防小鼠因维生素 A 营养缺乏引起的血清维生素 A 浓度的降低,但对肝脏维生素 A 的含量无影响。

A Pharmacodynamic Study of Sustained Release Vitamin A Injection

This experiment was designed to estimate the pharmacodynamic effects of a sustained release vitamin A injection in mice.One hundred eighty mice fed by the ration deficient vitamin A were devided into two series (ip and im).Each series was devided into five groups:group 1,NS;group 2,vitamin A emulsion 0.05mg/10g;group 3-5,sustained release vitamin A 0.025,0.05,0.1 mg/10g.The liver and serum vitamin A concentrations were analyzed by the reverse phase high performance liquid chromatography (Backman 344M). The results showed that the vitamin A deficiency model was brought on in the mice fed by the ration deficientin vitamin A and the sustained release vitamin A injection,ip or im,could prevent the decrease of serum vitamin A concentration for these animals.