原发性无色素性恶性黑色素瘤的临床病理特征分析

目的探讨原发性无色素性恶性黑色素瘤的临床病理特点及免疫组化在鉴别诊断中的作用.方法对10例发生在不同部位的原发性无色素性恶性黑色素瘤进行光镜观察并对全部病例做免疫组化染色.结果光镜下的细胞形态的多样性,组织结构的复杂性,以均未找到黑色素颗粒为主要特点,免疫组化染色S-100蛋白、HMB45及Vimentin的阳性率分别100.0%、80.0%和70.0%.结论 10例原发性无色素性恶性黑色素瘤病理学诊断比较困难,组织结构的变化特点对其诊断具有重要意义,免疫组织化学对其诊断和鉴别诊断有重要价值.

Analysis of clinical pathological features of primary amelanotic malignant melanoma

Objective To investigate the clinical pathological characteristics of primary amelanotic malignant melanoma and the use of immunohistochemistry in differential diagnosis.Methods Ten cases of primary amelanotic malignant melanoma were investigated at light microscopic level,and all cases were studied by immunohistochemical techniques.Results The principal features were the variety of cellular patterns and histological structures.Immunohistochemically,the positive rates of the expression of S-100 protein,HMB45 and Vimentin in 10 cases of primary amelanotic malignant melanoma were 100.0%,80.0% and 70.0% respectively.Conclusions The histo-pathological features of primary amelanotic malignant melanoma are very significant.Immunohistochemical staining plays an important role in its diagnosis and differential diagnosis with other tumors.