Activity of cytochrome P450 1A in the liver of CBA and CC57BR mice after prolonged repeated induction witho-aminoazotoluene |
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| Authors: | L. F. Gulyaeva V. V. Lyakhovich V. I. Kaledin |
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| Affiliation: | (1) Siberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and Biophysics, Novosibirsk;(2) Siberian Division of the Russian Academy of Sciences, Institute of Cytology and Genetics, Novosibirsk |
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| Abstract: | Cytochrome P450 1A activity in the liver of CBA and CC57BR mice sensitive and resistant to hepatocarcinogenic effects ofo-aminoazotoluene, respectively, was measured after prolonged (for several months) repeated administration of this agent. Repeated and single injections of this carcinogen produced similar effects on microsomal monooxygenases in CC57BR mice, but caused different changes in cytochrome P450 1A activity in the liver of CBA mice. Hence, enhanced inducibility of cytochrome P450 1A in CBA mice after prolonged treatment witho-aminoazotoluence probably contributes to their sensitivity to hepatocarcinogenic effects of this agent. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny Vol. 129, No. 3, pp. 280–282, March, 2000 |
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| Keywords: | CBA and CC57BR mice sensitivity to hepatocarcinoma repeated induction with o-aminoazotoluene cytochrome P450 1A |
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