| B淋巴细胞刺激因子及其受体介导的免疫细胞信号转导 |
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| 引用本文： | 秦琼,常艳,吴育晶,魏伟.B淋巴细胞刺激因子及其受体介导的免疫细胞信号转导[J].中国药理学通报,2011,27(5):593-596. |
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| 作者姓名： | 秦琼 常艳 吴育晶 魏伟 |
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| 作者单位： | 安徽医科大学临床药理研究所,抗炎免疫药理学省部共建教育部重点实验室,抗炎免疫药物安徽省工程技术研究中心,安徽,合肥,230032 |
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| 基金项目： | 国家自然科学基金资助项目，高等学校省级优秀青年人才基金项目，安徽省高等学校省级自然科学研究项目 |
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| 摘 要： | 肿瘤坏死因子家族成员B淋巴细胞刺激因子(BLyS)与其受体BAFF-R、BCMA和TACI特异性结合后,启动下游MAPK和NF-κB等抗凋亡信号通路,是维持免疫细胞生存、分化以及成熟的重要因素。该文就BLyS/BLyS-受体介导信号转导通路调节免疫细胞功能,参与免疫性疾病的发生以及各信号通路间的相互调控予以综述。
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| 关 键 词： | 免疫细胞 B淋巴细胞刺激因子 BAFF-R BCMA TACI 信号转导通路 |
BLyS and its receptors mediated signaling pathway of immune cells |
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| QIN Qiong,CHANG Yan,WU Yu-jing,WEI Wei.BLyS and its receptors mediated signaling pathway of immune cells[J].Chinese Pharmacological Bulletin,2011,27(5):593-596. |
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| Authors: | QIN Qiong CHANG Yan WU Yu-jing WEI Wei |
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| Institution: | (Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatoryand Immunopharmacology of Education Ministry of China,Anhui Engineering Technology Research Center of Anti-inflammatory and Immunodrugs,Hefei 230032,China) |
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| Abstract: | B lymphocytes stimulating factor of the TNF family,binds to its different receptors,BAFF-R,BCMA and TACI,then activates downstream signaling pathway,such as MAPK and NF-κB signaling,which are essential for the development of immune cells survival,differentiation and maturation.In this paper,BLyS/BLyS-receptor mediated signaling pathway involved in the immunological diseases through regulating immune cells function and the interaction between each signaling pathway are reviewed. |
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| Keywords: | B BAFF-R BCMA TACI |
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