| 黄连碱对L-NAME诱导高血压大鼠胸主动脉功能的影响 |
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| 引用本文： | 陈柏年,于晓彦,孙加琳,时丽丽,张恒艾,郭晶,方莲花,秦海林,杜冠华.黄连碱对L-NAME诱导高血压大鼠胸主动脉功能的影响[J].中国药理学通报,2011,27(5):610-613. |
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| 作者姓名： | 陈柏年 于晓彦 孙加琳 时丽丽 张恒艾 郭晶 方莲花 秦海林 杜冠华 |
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| 作者单位： | 中国医学科学院·北京协和医学院药物研究所,北京,100050 |
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| 基金项目： | 重大新药创制科技重大专项，国家自然科学基金资助项目 |
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| 摘 要： | 目的探讨黄连碱对L-NAME致高血压大鼠胸主动脉舒缩功能的影响。方法采用NO合酶抑制剂L-NAME制备大鼠高血压模型,然后每天灌胃给予黄连碱低(10 mg.kg-1)、中(30 mg.kg-1)、高(100 mg.kg-1)3个剂量;给药干预6周后采用体外血管环活性评价方法,评价各组大鼠胸主动脉的收缩和舒张功能。结果 L-NAME诱导大鼠高血压模型,其胸主动脉的收缩和舒张功能均受到影响。给予黄连碱6周,黄连碱可明显增强L-NAME诱导高血压大鼠血管平滑肌对细胞内钙释放引起的收缩反应,并降低外钙内流引起的血管收缩能力,但对大鼠血压无影响,对血管的收缩功能和内皮依赖的舒张功能影响不大。结论 L-NAME制备大鼠高血压模型主要与NO的减少有关,而黄连碱可能影响IP3-Ca2+通路,对L-NAME诱导大鼠高血压没有降压作用。
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| 关 键 词： | 黄连碱 高血压 胸主动脉 血管功能 L-NAME 一氧化氮 |
Effect of coptisine on the function of isolated thoracic aorta of L-NAME induced hypertensive rats |
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| CHEN Bai-nian,YU Xiao-yan,SUN Jia-lin,SHI Li-li,ZHANG Heng-ai,GUO Jing,FANG Lian-hua,QIN Hai-lin,DU Guan-hua.Effect of coptisine on the function of isolated thoracic aorta of L-NAME induced hypertensive rats[J].Chinese Pharmacological Bulletin,2011,27(5):610-613. |
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| Authors: | CHEN Bai-nian YU Xiao-yan SUN Jia-lin SHI Li-li ZHANG Heng-ai GUO Jing FANG Lian-hua QIN Hai-lin DU Guan-hua |
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| Institution: | CHEN Bai-nian,YU Xiao-yan,SUN Jia-lin,SHI Li-li,ZHANG Heng-ai,GUO Jing,FANG Lian-hua,QIN Hai-lin,DU Guan-hua(Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China) |
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| Abstract: | Aim To investigate the effect of coptisine on the vascular activity of hypertensive rats treated by L-NAME.Methods Coptisine was orally administered for 6 weeks after the hypertension was established by L-NAME treatment in rats.Then the rat aorta was harvested to evaluate its vasoactivity induced by various stimulus.Results Chronic inhibition of nitric oxide synthesis by L-NAME led to sustained elevation of blood pressure of rats,as well as vascular dysfunction.Coptisine failed to block the increase of syst... |
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| Keywords: | L-NAME |
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