生酮饮食在大鼠心肌缺血再灌注损伤中的保护作用 |
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引用本文: | 安良香,刘志强,杨欣欣,窦珊珊,程丹富,程葆华.生酮饮食在大鼠心肌缺血再灌注损伤中的保护作用[J].中国心血管病研究杂志,2010,8(12):942-943. |
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作者姓名: | 安良香 刘志强 杨欣欣 窦珊珊 程丹富 程葆华 |
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作者单位: | 安良香,程丹富(日照市人民医院心电图室,山东省,276826);刘志强,杨欣欣,窦珊珊,程葆华(济宁医学院解剖教研室,山东省,276826) |
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摘 要: | 目的 研究生酮饮食(KD)在大鼠心肌缺血再灌注损伤中的保护作用.方法 分别给予SD雄性大鼠正常饮食(ND)和KD 6周后,结扎大鼠冠状动脉左前降支30 min,恢复再灌注60 min,通过观察心电图和心肌酶学指标,评价KD对大鼠心肌缺血再灌注损伤的保护作用.结果 KD减轻了大鼠心肌缺血再灌注损伤引起的ST段抬高,降低了乳酸脱氢酶和肌酸激酶的水平.结论 KD对大鼠心肌缺血再灌注损伤具有保护作用.
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关 键 词: | 生酮饮食 缺血再灌注 正常饮食 心电图 |
Protective function of ketogenic diet( KD ) on myocardial ischemia-reperfusion injury in rats |
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Institution: | AN Liang-xiang, LIU Zhi-qiang, YANG Xin-xin, et al.(Department of Electrocardiogram room, the People's Hospital of Rizhao City, Rizhao 276826, China) |
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Abstract: | Objective To investigate protection of KD on myocardial ischemia-reperfusion injury in rats. Methods After pretreatment normal diet(ND) and KD respectively in male rats for 6 weeks all the rats were ligated with the left anterior descending coronary arteries for 30 min and then reperfused for 60 rain. The protection of KD on myocardial ischemia-reperfusion injury was evaluated by ECG monitoring and CK measurement. Results KD alleviated the elevation of ST segment induced by myocardial ischemia-reperfusion injury and decreased the levels of LDH and CK. Conclusion KD was protective on myocardial ischemia-reperfusion injury in rats. |
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Keywords: | Ketogenic diet Ischemia-reperfusion Normal diet Electrocardiogram(EGG) |
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