冠状动脉粥样硬化性心脏病患者糖代谢异常临床研究

目的:探讨冠心病患者糖代谢异常情况及临床特点。方法:符合冠心病诊断纳入标准的择期行冠脉造影的住院患者连续入选为研究对象,共收集有效病例201例。其中既往确诊为糖尿病38例,未确诊糖尿病的163例冠心病患者均行口服葡萄糖耐量试验(OGTT),并检测体重指数(BMI)、腰围、血压、血脂等。结果:201例中,已确诊糖尿病为38例(18.91%),经OGTT确诊冠心病合并糖尿病44例(21.89%),冠心病合并单纯糖耐量减低59例(29.35%),冠心病合并单纯空腹血糖受损15例(7.46%),冠心病合并空腹血糖受损及糖耐量减低为5例(2.49%),冠心病合并正常糖代谢40例(19.9%)。糖尿病组、糖耐量减低组、空腹血糖受损组与正常血糖组比较,腰围、体重指数、血压、血脂具有明显差异。结论:冠心病住院患者中多数合并糖代谢异常,糖代谢异常的冠心病患者存在明显的超重、血压、血脂异常,尽早通过OGTT试验发现糖代谢异常人群,并进行早期干预是非常必要的。

Study on the prevalence of abnormal glucose metabolism and clinical features in patients with coronary artery disease

Objective:To investigate the situation of abnormal glucose metabolism and clinical features in patients with coronary artery disease.Methods: 201 Scheduled hospital admitted inpatients with CAD were consecutively recruited,38 patients were previously diagnosed diabetes mellitus,OGTT were performed to characterize the glucose metabolism status.BMI,blood lipids and other clinical features were studied.Results: 163 CAD patients were performed OGTT,44 cases were diagnosed as DM,59 cases were IGT,15 cases were IFG,5 cases were IGT and IFG,and 40 cases with normal glucose tolerance.Among all CAD patients,total abnormal glucose metabolism made up 80.1%.Compared with normal glucose metabolism,DM,IFG group and IGT group showed significant BMI,WC and blood lipids abnormality.Conclusion:This survey highlights the frequency of abnormal glucose metabolism is considerably more common than normal glucose regulation in patients with CAD.Significant abnormal body weight and dislipidemia existed in CAD patients with abnormal glucose metabolism,OGTT easily discloses the glucometabolic status and should be a routine procedure in diagnosis of such patients.