乳腺癌前哨淋巴结临床病理的研究

目的：探讨乳腺癌前哨淋巴结能否准确反映腋窝淋巴结转移情况，方法对36例例早期乳腺癌，常规HE染色检测腋窝淋巴结，对HE染色阴性的前哨淋巴结及所属非前啉巴结，连续切片、免疫组化染色，检测其肿瘤的转移情况，结果常规病理检测36例中，10例腋窝有转移，其中2例仅哨淋巴结有肿瘤转移，连续切片，组化检测26例阴性的前哨淋巴结共61例，非前哨淋巴结406枚，2例（2枚）仅前哨淋巴结发现有肿瘤转移，余245例前哨淋巴结及非前哨淋巴结无肿瘤转移，HE染色的检测阴性的前哨淋巴结患者假阴性率为7．7％（2／26）。结论早期腺癌前哨淋巴结可以准确反映腋窝巴结转移情况。

Clinicopathological Study of Sentinel Lymph Nodes in Breast Carcinoma

Objective To test whether the histology of the sentinel lymph node(SLN) can accurately predict the histology of the rest of the axillary lymph nodes(ALNs).Methods Thirty six patients with early breast carcinoma were studied.All lymph nodes were subjected to routine histology(hematoxylin and eosin,HE).Additional sections from HE negative SLN and NSLN were examined for the presence of occult metastatic carcinoma by serial sectioning(SS) and cytokeratin immunohistochemical stains(IHC).Results Ten of the 36 patients were found to have metastasis in SLNs by HE.Applying SS and IHC to the 61 tumor free SLNs in other 26 patients showed additional 2 tumor involved nodes for a conversion rate of 7.7%(2/26).The 406 NSLNs in the 26 patients examined by SS and IHC were not identified any additional metastases.Conclusion The status of the SLNs can accurately predict total axillary status in early breast carcinoma.