| 2型糖尿病肾病患者血清白介素18、脂联素检测的临床意义 |
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| 引用本文： | 唐灵,陈春莲,苏桂兰,甄瑞峰. 2型糖尿病肾病患者血清白介素18、脂联素检测的临床意义[J]. 世界中医药, 2011, 6(4): 297-300 |
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| 作者姓名： | 唐灵 陈春莲 苏桂兰 甄瑞峰 |
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| 作者单位： | 广西桂林医学院附属医院,广西省桂林市乐群路95号,541001 |
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| 摘 要： | 目的：探讨白介素18和脂联素在2型糖尿病肾病（DN）中的水平变化及意义。方法：选择97例2型糖尿病患者,根据尿白蛋白排泄率（UAER）分为3组：正常蛋白尿组,微量蛋白尿组和大量蛋白尿组,另选健康体检者35例为对照组。采用酶联免疫吸附法（ELISA）检测血清脂联素和白介素18（Interleukin-18,IL-18）,比较各组间的差异。结果：3组患者血清IL-18明显高于正常对照组（P〈0.05）,正常蛋白尿组血清脂联素低于对照组,微量蛋白尿组、大量蛋白尿组血清脂联素高于对照组,差异有统计学意义（P〈0.01）。IL-18与病程、SBP、HbA1c、FPG、TG、TC、LDL-C、BUN、Scr、UAER呈不同程度正相关（P〈0.01）,与HDL-C呈负相关（P〈0.01）,与其他指标无相关性。脂联素与病程、SBP、BUN、Scr、UAER呈正相关（P〈0.01）。结论：IL18和脂联素与2型DN的发生、发展有关,二者联合检测有助于DN早期诊断及临床治疗监测。
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| 关 键 词： | 糖尿病肾病 白介素18 脂联素 |
| 收稿时间： | 2011-06-29 |
Clinical Significance of Serum Interleukin-18 and Adiponectin Level in the Type 2 Diabetic Patients with Nephropathy |
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| Tang Ling,Chenchunlian,Su Guilan,et al.. Clinical Significance of Serum Interleukin-18 and Adiponectin Level in the Type 2 Diabetic Patients with Nephropathy[J]. World Chinese Medicine, 2011, 6(4): 297-300 |
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| Authors: | Tang Ling Chenchunlian Su Guilan et al. |
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| Affiliation: | Tang Ling,Chenchunlian,Su Guilan,et al.(The Affiliated Hospital of Guangxi Guilin Medical College,Add:No.95,Lequn Rood,Guilin,Guangxi Province,Post code:541001) |
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| Abstract: | Objective:To investigate the changes and significance of interleukin-18(IL-18) and adiponectin in type 2 diabetic patients with nephropathy.Methods:This study included 96 patients with type 2 diabetes mellitus,These patients were divided into three groups according to the urinary albumin excretion rate(UAER):normalalbuminuria group,micro-albuminuria group and macro-albuminuria,and 35 healthy subjects as control group.Serum adiponectin and IL-18 was measured by enzyme linked immunosorbent assay(ELISA),Compar... |
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| Keywords: | Diabetic Nephropathy Interleukin-18 Adiponectin |
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