| 自体纯化CD34+细胞移植治疗自身免疫性疾病14例的临床观察 |
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| 引用本文： | 文钦,张诚,陈幸华,刘耀,高蕾,高力,孔佩艳,张曦.自体纯化CD34+细胞移植治疗自身免疫性疾病14例的临床观察[J].国际检验医学杂志,2011,32(11):1160-1162. |
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| 作者姓名： | 文钦 张诚 陈幸华 刘耀 高蕾 高力 孔佩艳 张曦 |
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| 作者单位： | 第三军医大学新桥医院血液科/重庆市医学重点学科,重庆,400037 |
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| 基金项目： | 国家自然科学基金资助项目，重庆市自然科学基金重点资助项目，第三军医大学临床科研基金资助项目 |
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| 摘 要： | 目的 探讨自体纯化CD34+细胞移植治疗自身免疫性疾病(AID)的疗效.方法 对14例自身免疫性疾病患者进行自体纯化CD34+细胞移植.采用环磷酰胺(CTX)+G-CSF动员外周血干细胞,通过CliniMACS细胞分选仪分选CD34+细胞并冻存.预处理方案:8例采用氟达拉滨(FDB)+抗胸腺细胞球蛋白(ATG)+CT...
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| 关 键 词： | 自身免疫疾病 外周血干细胞移植 CD34+细胞 |
Transplantation of purified autologous peripheral blood CD34+ cells in the treatment of 14 cases with autoimmune diseases |
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| Wen Qin,Zhang Cheng,Chen Xinghua,Liu Yao,Gao Lei,Gao Li,Kong Peiyan,Zhang Xi.Transplantation of purified autologous peripheral blood CD34+ cells in the treatment of 14 cases with autoimmune diseases[J].International Journal of Laboratory Medicine,2011,32(11):1160-1162. |
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| Authors: | Wen Qin Zhang Cheng Chen Xinghua Liu Yao Gao Lei Gao Li Kong Peiyan Zhang Xi |
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| Institution: | Wen Qin,Zhang Cheng,Chen Xinghua,Liu Yao,Gao Lei,Gao Li,Kong Peiyan,Zhang Xi(Department of Hemotology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China) |
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| Abstract: | Objective To explore the therapeutic effect of transplantation of purified autologous peripheral blood CD34+ cells in the treatment of autoimmune diseases.Methods 14 cases of patients with various autoimmune diseases were treat with autologous transplantation of purified peripheral blood CD34+ cells.Autologous peripheral blood cells were mobilized with the regimen of cycolphosphamide plus rhG-GSF,and then the CD34+ cells were selected by CliniMACS.Before treated with CD34+ cells transplantation,8 cases were... |
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| Keywords: | autoimmune diseases peripheral blood stem cell transplantation CD34 cell |
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