Dephosphorylation of eNOS on Thr495 after transient forebrain ischemia in gerbil hippocampus |
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| Authors: | Hashiguchi Akihito Yano Shigetoshi Morioka Motohiro Hamada Junichiro Kochi Masato Fukunaga Kohji |
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| Affiliation: | Department of Neurosurgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto City, Kumamoto, Japan. 000m9033@med.stud.kumamoto-u.ac.jp |
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| Abstract: | We investigated phosphorylation of endothelial nitric oxide synthase (eNOS) at two major sites, Ser1177 and Thr495, which has a critical role to control its activity, in the gerbil hippocampal microvasculature after transient forebrain ischemia. Ser1177 phosphorylation was unchanged by 24 h after reperfusion, despite post-ischemic up-regulation of eNOS protein. However, Thr495 phosphorylation significantly and persistently decreased by 48 h. We here defined the changes in eNOS phosphorylation in vivo following brain ischemia/reperfusion. (ischemia). |
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