首页 | 本学科首页   官方微博 | 高级检索  
检索        


Electrophysiological analysis of motor cortical plasticity after cortical lesions in newborn rats
Authors:G Kartje-Tillotson  EJ Neafsey  AJ Castro
Institution:1. Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA;2. Neurological Institute of Athens, Athens, Greece;3. Gladstone Institute of Neurological Disease, San Francisco, CA, USA;1. Biotrial Pharmacology, 7-9 rue Jean-Louis Bertrand, 35042, Rennes, France;2. Plate-Forme H2P2, Université de Rennes 1, Biosit, 2 Av. du Prof. Léon Bernard, 35043, Rennes, France;1. Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia;2. The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia;1. Graduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, 90035-003, Porto Alegre, Brazil;2. Graduate Program in Biological Sciences: Physiology, Universidade Federal do Rio Grande do Sul, 90035-003, Porto Alegre, Brazil;3. Pain Pharmacology and Animal Models of Neuromodulation Laboratory, Department of Pharmacology, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, 90050-170, Porto Alegre, Brazil;4. Animal Experimentation Unit, Hospital de Clínicas de Porto Alegre Graduate Research Group, 90035-003, Porto Alegre, Brazil;5. Department of Morphological Sciences, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, Brazil;6. Graduate Program in Health and Human Development, Centro Universitário Unilasalle, 92010-000, Canoas, Brazil;1. First Department of Neurology, St. Anne’s University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic;2. Central European Institute of Technology (CEITEC), Masaryk University, Brain and Mind Research Program, Brno, Czech Republic
Abstract:Intracortical microstimulation of the motor cortex in normal adult rats evoked low threshold contralateral forelimb movements and high threshold ipsilateral movements. Ablation of the opposite sensorimotor cortex in adult animals did not alter these thresholds. However, stimulation of the unablated hemisphere in adult rats that sustained unilateral sensorimotor cortical lesions as neonates elicited low threshold ipsilateral forelimb movements that were similar to contralateral movements. These low threshold ipsilateral movements may be mediated via aberrant corticofugal pathways which are known to develop following neonatal cortical lesions.
Keywords:neonatal lesions  corticofugal plasticity  intracortical microstimulation
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号