In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug |
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Authors: | Kim Beom Su Won Myoung Lee Kang Min Kim Cheo Sang |
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Affiliation: | Laboratory of Enzyme Technology, College of Natural Science, Chonju, Republic of Korea. |
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Abstract: | We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol(R) HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control. |
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