小剂量红霉素治疗支原体肺炎临床评价

目的观察小剂量红霉素治疗肺炎支原体肺炎的临床效果。方法将我科收治的肺炎支原体肺炎随机分成小剂量组和常规剂量组，每天分别予小剂量（10mg／kg）和常规剂量（30mg／kg）注射用乳糖酸红霉素治疗，10d为一疗程，对两组的临床表现、医技检查结果及不良反应进行对比分析。结果两组发热消退时间（t=1．0642，P〉0．05）、咳嗽缓解时间（t=0．8451，P〉0．05）、哕音消失时间（t=0．6721，P〉0．05）、血白细胞恢复时间（t=0．8723，P〉0．05）及治疗10d后X线胸片阴影消散率（χ2=2．085，P〉0．05）等方面比较差异无统计学意义；两组穿刺局部疼痛率比较差异无统计学意义（χ2=2．040，P〉0．05），但恶心（χ2=33．38，P〈0．05）、呕吐（χ2=52．23，P〈0．05）、食欲缺乏（χ2=54．37，P〈0．05）等胃肠道症状比较差异均有统计学意义；2周后复查丙氨酸转氨酶差异也有统计学意义（χ2=78．13，P〈0．05）。结论小剂量红霉素治疗肺炎支原体肺炎效果肯定，不良反应少。

Evaluation of the Clinical Efficacy of Low Dose Erythromycin in Treating Mycoplasma Pneumonia

Objective To observe the clinical efficacy of low dose erythromycin in treating mycoplasma pneumonia.Methods Patients with mycoplasma pneumonia in our hospital were randomly divided into two groups(low-dose group and control group).Low-dose group was administered with intravenous drip of low dose erythromycin lactobionate(10 mg/kg) once a day and control group was administered with intravenous drip of routine dose erythromycin lactobionate(30 mg/kg) once a day.One course of treatment was 10 d.The clinical efficacy,iatrical examinations and adverse reaction were compared after treatment.Results There was no statistical significance in regression time of fever(t=1.0642,P>0.05),coughing released time(t=0.8451,P>0.05),rales extinction time(t=0.6721,P>0.05),leucocyte in blood coincidnece time(t=0.8723,P>0.05),shadow dispersion rate by X-ray 10 days after treatment(χ2=2.085,P>0.05);The differences for local pain by paracentesis of the two groups showed no significant differences(χ2=2.040,P>0.05),the incidence rates of gastrointestinal symptoms such as nausea(χ2=33.38,P<0.05),vomiting(χ2=52.23,P<0.05) and anorexia(χ2=54.37,P<0.05) showed significant differences;The differences of ALT in the two groups after two weeks of review showed significant differences(χ2=78.13,P<0.05).Conclusion Low dose erythromycin is effective in the treatment of mycoplasma pneumonia with fewer adverse reactions.