噻氯匹啶对老年常见血栓性疾病患者血小板聚集性及血液流变学的影响

对42名老年常见血栓性疾病非急性梗塞期患者随机给予噻氯匹啶(ticlopidine,TP)125～250 mg/日或阿斯匹林(aspirin,ASA)162.5mg/日,疗程36～39日。服药前后分别测定三项血小板(platelct,Pt)聚集指标,TP组尚同步作血液流变学及血液粘弹性测定。结果发现:对于二磷酸腺苷(ADP)诱导的Pt聚集,TP有极显著的抑制作用(P<0.01),且TP之抑制作用超过ASA(P<0.05)。TP能明显延长出血时间(BT)(P<0.05)、对多项血液流变学及血液粘弹性指标无影响、也无明显副作用。作者认为TP防治血栓性疾病可能是通过降低Pt聚集率和延长BT而起作用的。

The effect of ticlopidine on platelet aggregation and hemorrheology for the aged patients with common thrombotic disorders

A comparison of the effect of ticlopidinc (125-250 mg daily) with that of aspirin (162.5 mg daily) on antiplatelet aggregation was reported. The drugs were given randomly to 42 aged patients with common thrombotic disorders (non-acute infarction pcriod) and was followed up for 36 to 39 days. Three parameters of platelct aggregation were measured both before and after the treatment. At the meantime hemorrheological parameters in ticlopidine group were measured. The results showed that ticlopidine inhibited the platelet aggregation rate induced by adenosine diphosphate markedly (P<0.01), and the inhibiting action of ticlopidine was much more than that of aspirin (P<0.05). Bleeding time was significantly prolonged by ticlopidine (P<0.05). No change of hemorrheological parameters, and also no aide effects were found in patients treated with ticlopidine. We regarded that ticlopidine was used to prevent thrombotic disorders was probably due to its action of reducing platelet aggregation and prolonging the bleeding time.