| 盐酸甜菜碱的镇静和解热镇痛作用 |
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| 引用本文： | 许德义,杨德林,丁一上,邓平. 盐酸甜菜碱的镇静和解热镇痛作用[J]. 药学学报, 1986, 21(1): 61-64 |
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| 作者姓名： | 许德义 杨德林 丁一上 邓平 |
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| 作者单位： | 石河子医学院药理教研室 新疆石河子(许德义，杨德林，丁一上)，石河子医学院药理教研室 新疆石河子(邓平) |
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| 摘 要： | 甜菜碱(betaine)化学名称三甲基铵乙内酯,系甘氨酸的三甲基衍生物,临床所用含甜菜碱的药物有盐酸甜菜碱(betaine hydrochloride)氯醛甜菜碱(chloral betaine)和烟酸甜菜碱(betaine nicotinate)在这些药物中甜菜碱仅作为载体发挥作用。研究表明:甜菜
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| 关 键 词： | 甜菜碱 镇静 解热 镇痛 |
| 收稿时间： | 1984-12-19 |
THE SEDATIVE, ANTIPYRETIC AND ANALGESIC EFFECTS OF BETAINE HYDROCHLORIDE |
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| XU De-Yi,YANG De-Lin,DING Yi-Shang and DENG Ping. THE SEDATIVE, ANTIPYRETIC AND ANALGESIC EFFECTS OF BETAINE HYDROCHLORIDE[J]. Acta pharmaceutica Sinica, 1986, 21(1): 61-64 |
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| Authors: | XU De-Yi YANG De-Lin DING Yi-Shang DENG Ping |
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| Abstract: | When betaine hydrochloride was given orally 250～1000 mg/kg, the motor activity of mice was reduced 50～81%. The hypnotic effect of pentobarbital was markedly increased after oral administration of betaine hydrochloride at the dosage of 500 mg/kg or 1000 mg/kg. Analgesic effect of betaine was demonstrated in mice by the hot plate method (55℃) and the acetic acid writhing test when given intraperitoneally at the dosage of 540 mg/kg or 900 mg/kg. The analgesic effect of betaine (500 mg/kg) was antagonized by prior administration of atropine (5 mg/kg).Betaine hydrochloride (500 mg/kg) given by gastric intubation was shown to have antipyretic effect in rabbits with ⅳ TAB vaccine fever, but not in normotheric rabbits. |
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| Keywords: | Betaine Sedatives Analgesics Antipyretics |
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