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Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers
Authors:Matthias G Pauthner  Joseph P Nkolola  Colin Havenar-Daughton  Ben Murrell  Samantha M Reiss  Raiza Bastidas  Jérémie Prévost  Rebecca Nedellec  Benjamin von Bredow  Peter Abbink  Christopher A Cottrell  Daniel W Kulp  Talar Tokatlian  Bartek Nogal  Matteo Bianchi  Hui Li  Jeong Hyun Lee  Salvatore T Butera  Dennis R Burton
Institution:1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA;3. IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA;4. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;5. Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA;6. Division of Infectious Diseases, Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA;7. Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada;8. Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montreal, QC H2X 0A9, Canada;9. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA;10. Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;11. Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA;12. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA;13. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;14. Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada;15. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA;16. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;17. Departments of Biological Engineering and Materials Science & Engineering, MIT, Cambridge, MA 02139, USA;18. Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands;19. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA
Abstract:
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  • Keywords:HIV vaccine  vaccination  neutralizing antibodies  correlates of protection  BG505  tier 2 protection  non-human primates  ADCC
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