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Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta
Authors:Ling-juan Zhang  Stella Xiang Chen  Christian F. Guerrero-Juarez  Fengwu Li  Yun Tong  Yuqiong Liang  Marc Liggins  Xu Chen  Hao Chen  Min Li  Tissa Hata  Ye Zheng  Maksim V. Plikus  Richard L. Gallo
Affiliation:1. School of Pharmaceutical Sciences, Xiamen University, Xiamen, China;2. Department of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA;3. Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA;4. Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA;5. Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing 210042, China;6. Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:innate immunity  dermal white adipose tissue  dermal fibroblasts  adipocyte progenitors  adipocytes  infection  cathelicidin  antimicrobial peptides  transforming growth factor beta
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