沙苑子总黄酮对 SHR 的降压及血流动力学影响

目的 :观察沙苑子总黄酮对自发性高血压大鼠 (SHR)的降压作用及在麻醉状态下对其血流动力学的影响。方法 :采用尾动脉测压法及多导生理记录仪分别记录沙苑子总黄酮灌胃后血压及血流动力学的变化。结果 :沙苑子总黄酮灌胃 (100 ,200mg·kg^-1)使清醒SHR血压明显下降 (分别下降 7.1% ,P<0.05及9.3% ,P<0.01) ,动物心率无明显变化。沙苑子总黄酮 (200mg·kg-1)对麻醉SHR心输出量和心率影响不大 ,但可显著降低SHR的总外周阻力 (下降20% ,P<0.05) ,从而引起SHR收缩压、舒张压的显著下降 ,其中舒张压的下降更为明显。结论 :沙苑子总黄酮有明显的降压作用 ,主要是通过降低外周阻力引起的。

Depressive Effect of Total Flavonoid Fraction of Asttragalus complanatus R.Br and its Influence upon Hemodynamics in SHR

Objective: To investigate effects of total flavonoid fraction of Asttragalus complanatus on blood pressure in conscious spontaneously hypertensive rats(SHR) and hemodynamics in anesthetized SHR. Method: Blood pressure was recorded with tail-culf method and hemodynamics was recorded with polygraph after administration of total flavonoid fraction of Asttragalus complanatus. Result: Total flavonoid fraction of Asttragalus complanatus (100,200 mg·kg^-1) could decrease blood pressure of conscious SHR(decreasing 7.1%, P<0.05 and 9.3%, P<0.01 respectively). Meanwhile, there was no significant change in heart rate(HR). R Br (200 mg·kg^-1) could decrease total peripheral resistance (TPR) (decreasing 20%, P<0.05) but did not influence the cardiac output(CO) and heart rate in anesthetized SHR. Conclusion: Total flavonoid fraction of Asttragalus complanatus possesses obvious hypotensive effect, mainly by means of decreasing the TPR.