| 维生素A水平对孕期大鼠脂质过氧化及抗氧化系统的影响 |
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| 引用本文： | 任国峰,黄忆明,刘富强.维生素A水平对孕期大鼠脂质过氧化及抗氧化系统的影响[J].实用预防医学,2001,8(3):173-175. |
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| 作者姓名： | 任国峰 黄忆明 刘富强 |
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| 作者单位： | 中南大学湘雅医学院营养与食品卫生学教研室 |
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| 摘 要： | 目的研究维生素A(VA)水平对孕期大鼠脂质过氧化及抗氧化系统的影响.方法健康雌性受孕SD大鼠24只,按体重随机分为A(VA缺乏组),B(正常对照组),C(VA5倍剂量组),D(VA15倍剂量组)四组.每组6只,饲以实验合成饲料,实验期为合笼前两周至孕期第19天.观察指标有血清和肝脏中VA含量、丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性.结果D组大鼠血清和肝脏中SDD活性明显下降(P＜0.05),MDA含量显著升高(P＜0.05).结论大剂量的VA摄人可使孕期大鼠SOD活性下降,脂质过氧化反应明显增强.而VA轻度及5倍过量似对孕期大鼠脂质过氧化无影响.
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| 关 键 词： | 维生素A 孕期 脂质过氧化 SOD |
| 文章编号： | 1006-3110(2001)03-0173-03 |
| 修稿时间： | 2001年4月16日 |
Influence of Vitamin A Level on Lipid Peroxidation and Antioxidation Sysitem in Pregnant Rats. |
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| REN Guo-feng,HUANG Yi-ming,LIU Fu-qiang.Influence of Vitamin A Level on Lipid Peroxidation and Antioxidation Sysitem in Pregnant Rats.[J].Practical Preventive Medicine,2001,8(3):173-175. |
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| Authors: | REN Guo-feng HUANG Yi-ming LIU Fu-qiang |
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| Abstract: | Objective To study the influence of vitamin A level on lipid peroxidation and antioxidation system in Pregnant Rats . Methods 24 pregnant SD rats were divided randomly and equally into 4 groups according to the weight,i.e.,A(vitamin A deficiency group),B (control group).C(vitamin A 5 times dose group),D(vitamin A 15 times dose group).fed experimental diet.The experiment period was 2 weeks before gestation to the 19th day of pregnancy.Their serum and liver vitamin A,MDA and SOD were studied. Result In vitamin A 15 times dose group.the SOD activities of serum and liver decreased significantly(P<0.05),and MDA content of serum and liver increased markedly (P<0.05). Conclusion Large dose vitamin A results in decreaes of SOD activities and increase of lipid peroxidation.It seems that slight deficiency of vitamin A and 5 times dose didn't influence lipid peroxidation in pregnancy rats. |
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| Keywords: | Vitamin A Rat Pregnancy Lipid peroxidation SOD |
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