染料法乳腺癌前哨淋巴结活检的临床应用

为了探讨影响染料法乳腺癌前哨淋巴结活检（SLNB）成功率的因素及其可能机制,使用亚甲蓝染色法对89例乳腺癌进行SLNB,分析其可能的影响因素和机制.结果：78例成功检出前哨淋巴结（SLN）,检出率为87.6%.术前未触及肿大淋巴结者,SLN检出率明显高于可触及肿大淋巴结者（P＜0.05）,而假阴性率显著低于后者,P＜0.05;实验后期64例SLNB检出率高于实验早期25例的检出率,P＜0.05.初步研究结果提示,腋窝淋巴结肿大影响SLNB的检出率;SLNB技术学习曲线也可影响SLN的检出率.SLNB可用于指导乳腺癌的外科治疗.

Sentinel lymph node biopsy with living dyes in breast cancer patients

The objective of this study was to explore the factors that might affect the success rate of sentinel lymph node biopsy(SLNB)with living dye in patients with breast cancer.Eighty-nine patients with breast cancer were detected for sentinel lymph nodes(SLN)by using methylene blue,and the possible factors that might affect the success rate of SLNB and the mechanisms were analyzed.Seventy-eight cases(87.6%)were confirmed by SLNB.The rate of detection of SLN with palpable axillary node(s)was lower(P<0.05),while the pseudo-negative rate was higher than that with no palpable axillary nodes,P<0.05.The rate of detection of SLN in the first 25 cases was lower than that in the latter 64 patients,P<0.05.In conclusion,the enlarged axillary node may affect the success rate of SLNB.The rate of SLN detection could be improved by repeated practice.SLNB can direct the surgical treatment of breast cancer.