| 固本喘嗽康颗粒的镇咳、祛痰、平喘实验研究 |
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| 引用本文： | 朱希卓,甘雨,张宏,乔世举,孟莉,包玉龙,李健,崔明景,刘禾,宋达夫.固本喘嗽康颗粒的镇咳、祛痰、平喘实验研究[J].中南药学,2008,6(3):277-280. |
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| 作者姓名： | 朱希卓 甘雨 张宏 乔世举 孟莉 包玉龙 李健 崔明景 刘禾 宋达夫 |
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| 作者单位： | 1. 辽宁中医药大学,沈阳,110032
2. 辽宁省中医研究院,沈阳,110034 |
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| 摘 要： | 目的观察固本喘嗽康颗粒对哮喘的药效作用。方法通过动物模型引咳、祛痰和引喘实验来观察其镇咳、祛痰、平喘效果。结果高、中、低剂量的固本喘嗽康颗粒均能显著地抑制浓氨水所致小鼠咳嗽潜伏期和咳嗽次数;能增加小鼠呼吸道的酚红排泌量;还能显著地延长豚鼠哮喘潜伏期,对豚鼠离体气管平滑肌痉挛具有明显的松弛作用。结论固本喘嗽康颗粒具有明显的镇咳、祛痰、平喘作用。
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| 关 键 词： | 固本喘嗽康 哮喘 实验研究 |
| 文章编号： | 1672-2981(2008)03-0277-04 |
| 修稿时间： | 2008年1月28日 |
Experimental study on the antitussive,apophlegmatic and antiasthmatic effect of Gubenchuansoukang granules |
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| ZHU Xi-zhuo,GAN Yu,ZHANG Hong,QIAO Shi-ju,MENG Li,BAO Yu-long,LI Jian,CUI Ming-jing,LIU He,SONG Da-fu.Experimental study on the antitussive,apophlegmatic and antiasthmatic effect of Gubenchuansoukang granules[J].Central South Pharmacy,2008,6(3):277-280. |
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| Authors: | ZHU Xi-zhuo GAN Yu ZHANG Hong QIAO Shi-ju MENG Li BAO Yu-long LI Jian CUI Ming-jing LIU He SONG Da-fu |
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| Institution: | ZHU Xi-zhuo,GAN Yu,ZHANG Hong,QIAO Shi-ju,MENG Li,BAO Yu-long,LI Jian,CUI Ming-jing,LIU He,SONG Da-fu(1.Liaoning University of Traditional Chinese Medicine,Shenyang 110032;2.Liaoning Institute of Traditional Chinese Medicine,Shenyang 110034) |
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| Abstract: | Objective To observe the pharmacodynamic function of Gubenchuansoukang granules on asthma.Methods We observed the antitussive,apophlegmatic and antiasthmatic effect of the granules on such points as cough-inducing,asthma-inducing,and eliminating phlegm through mouse models.Results Hight,middle and low dose of Gubenchuansoukang granules were able to prolong cough latent period,decrease cough rate significantly in mice induced by ammonia solution,and increase the excretion of phenolsulfonphthalein in the trachea of mice.It could also prolong tussive latent period resulted from histamine phosphate in guinea pigs significantly,and relax the bronchus smooth muscles markedly in guinea pigs.Conclusion Gubenchuansoukang granules are antitussive,apophlegmatic and antiasthmatic. |
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| Keywords: | Gubenchuansoukang granule asthma experimental study |
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