尼莫地平对实验性腹膜粘连的防治作用

腹膜粘连是引起肠梗阻的原因之一。笔者以大鼠腹膜粘连模型研究钙离子拮抗剂尼莫地平对预防腹膜粘连的作用，结果对照组鼠均有腹膜粘连形成，粘连积分为（3．30±0．82），实验组鼠腹腔内注入尼莫地平后积分降至（2．0±0．76），P＜0．05，两次给药后降至（1．63±1．06），并有部分鼠未形成腹膜粘连。钙离子拮抗剂防治腹膜粘连的机理可能与该药具有抗血管收缩、抗缺血作用以及参与炎症调节、抑制血小板聚集、抑制胶原合成等作用有关。

PREVENTIVE EFFECT OF NIMODIPINUM ON EXPERIMENTAL PERITONEAL ADHESION

Peritoneal adhesion is a major cause of intestinal obstruction. This paper reports the effect of nimodipinum, a calcium channel blockade, on experimental peritoneal adhesion. All rats in the control group developed peritoneal adhesion after operation, with the adhesion score of 3. 30±0.82; but adhesion formation was significantly decreased in rats given nimodipinum intraperitoneally at the end of the operation, with the adhesion score of 2. 0±0. 76 (P<0. 05). Moreover, in the rats of nimodipinum groups that were given an extra dosage one or two days after the operation, the score was further reduced to 1. 63±1. 06, and even no ahesion formation was found in some of them. The results suggest that nimodipinum is beneficial to the prevention of experimental peritoneal adhesion.