Haemodynamic effects of oral aminorex and amphetamine in unanaesthetized beagle dogs |
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| Authors: | James A. Will and Gerald E. Bisgard |
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| Affiliation: | .Cardiovascular Research Laboratory, Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706;.Department of Veterinary Science, College of Agriculture and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706 |
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| Abstract: | The haemodynamic effects of four daily oral doses of 1·5 mg/kg of aminorex (as fumarate) were measured in unanaesthetized beagle dogs. A similar study was performed in another group of related animals using d-amphetamine sulphate (1 mg/kg). Both agents produced similar sympathomimetic effects consisting of transient rises in systemic and pulmonary arterial blood pressures over an eight-hour period after administration of either drug. Heart rate remained unchanged in the dogs receiving aminorex whereas it decreased in those receiving amphetamine. |
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