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| 温敏型液体栓塞材料的实验研究 | |
| 引用本文： | 盛希忠,刘作勤,武乐斌,唐军,赵成如,孔令斌,王勤. 温敏型液体栓塞材料的实验研究[J]. 实用放射学杂志, 2005, 21(12): 1233-1236 |
| 作者姓名： | 盛希忠 刘作勤 武乐斌 唐军 赵成如 孔令斌 王勤 |
| 作者单位： | 1. 山东大学医学院,山东,济南,250012 2. 山东省医学影像学研究所 3. 山东省医疗器械研究所 |
| 基金项目： | 国家高技术研究发展计划(863计划)资助项目,课题编号2002AA326100。 |
| 摘 要： | 目的合成一种新型温度敏感性液体栓塞材料并探讨其栓塞脑动静脉畸形(arteriovenous malformation,AVM)的可能性。方法应用氮-异丙基丙烯酰胺(N-isopropylacry lamide,NIPAM)和氮-正丙基丙烯酰胺(N-n-propylacrylamide,NNPAM)合成共聚物,进行物理性质测定和体外AVM模型栓塞试验。结果共聚物具有低临界溶解温度(lowercritical solubletem perature,LCST),具有水溶性和非粘附性特点,能成功栓塞体外AVM模型。结论共聚物为一种脑AVM血管内栓塞治疗的新型液体栓塞材料,可用于进一步动物实验。 |
| 关 键 词： | 温度敏感性共聚物 氮-异丙基丙烯酰胺 氮-正丙基丙烯酰胺 动静脉畸形 栓塞 介入放射学 |
| 文章编号： | 1002-1671(2005)12-1233-04 |
| 修稿时间： | 2005-02-16 |
Experimental Study of Thermosensitive Liquid Embolic Material |
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| SHENG Xi-zhong,LIU Zuo-qin,WU Le-bin,TANG Jun,ZHAO Cheng-ru,KONG Ling-bin,WANG Qin. Experimental Study of Thermosensitive Liquid Embolic Material[J]. Journal of Practical Radiology, 2005, 21(12): 1233-1236 | |
| Authors: | SHENG Xi-zhong LIU Zuo-qin WU Le-bin TANG Jun ZHAO Cheng-ru KONG Ling-bin WANG Qin |
| Abstract: | Objective To synthesize a thermosensitive liquid embolic material and to investigate its embolic feasibility in cerebralarteriovenous malformation(AVM).Methods The copolymer was synthesized with N-isopropylacrylamide(NIPAM) and N-n-propylacrylamide(NNPAM) and its properties were analyzed. The models of arteriovenous malformation(AVM) in vitro were embolized with thecopolymer.Results The copolymer had unique thermal behavior of lower critical soluble temperature (LCST) , it was soluble in water andnonadhesive and could embolize the AVM models in vitro successfully . Conclusion The copolymer is a new liquid embolic material for endovascular embolic treatment of AVM and may remain to be confirmed in further animal experiments. |
| Keywords: | thermosensitive copolymer N-isopropylacrylamide N-n-propylacrylamide arteriovenous malformation embolization interventional radiology |
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